1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor

Dopamine Receptor

Dopamine Receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous ligand for dopamine receptors. Dopamine receptors are implicated in many neurological processes, including motivation, pleasure, cognition, memory, learning, and fine motor control, as well as modulation of neuroendocrine signaling. Abnormal dopamine receptor signaling and dopaminergic nerve function is implicated in several neuropsychiatric disorders. Thus, dopamine receptors are common neurologic drug targets; antipsychotics are often dopamine receptor antagonists while psychostimulants are typically indirect agonists of dopamine receptors. There are at least five subtypes of dopamine receptors, D1, D2, D3, D4, and D5. The D1 and D5 receptors are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4receptors are members of the D2-like family.

Dopamine Receptor 相关产品 (131):

Cat. No. Product Name Effect Purity
  • HY-B0407A
    Chlorpromazine hydrochloride Antagonist 99.83%
    Chlorpromazine Hydrochloride是D25HT2A钾通道钠通道的拮抗剂。 Chlorpromazine与 D2 和 5HT2A 结合的 Ki 分别为363 nM和8.3 nM。
  • HY-B1081A
    Oxidopamine hydrobromide Activator >98.0%
    Oxidopamine (hydrobromide)是神经递质多巴胺拮抗剂,是一种广泛使用的神经毒素,可选择性地破坏多巴胺能神经元。
  • HY-19545A
    SCH 23390 hydrochloride Antagonist 99.31%
    SCH 23390 hydrochloride是有效的多巴胺受体D1拮抗剂,对D1和D5的Ki值分别为0.2和0.3 nM。
  • HY-12705A
    Bromocriptine mesylate Agonist 99.98%
    Bromocriptine mesylate 是一种有效的多巴胺 D2/D3 受体激动剂,结合多巴胺 D2 受体,pKi 为 8.05±0.2。
  • HY-N0304
    L-DOPA Agonist 99.72%
    L-DOPA是DOPA的天然形式,是多巴胺前体,可作用于帕金森氏病。
  • HY-19654
    GSK598809 Antagonist 99.73%
    GSK598809 是多巴胺 D3 受体 (DRD3) 的选择性拮抗剂,其pKi 值为 8.9。
  • HY-21098A
    PD-168077 maleate Agonist 98.44%
    PD-168077 maleate 是一个选择性的多巴胺 D4 受体激动剂,其 Ki 值为 9 nM。
  • HY-B2073A
    Clocapramine hydrochloride hydrate Antagonist
    Clocapramine hydrochloride hydrate 是多巴胺 D25-HT2A 受体拮抗剂。
  • HY-42110
    Dopamine serotonin antagonist-1 Antagonist 99.79%
    Dopamine serotonin antagonist-1是 dopamineserotonin 受体拮抗剂,对多巴胺D1,D2,D4和血清素S2A,S2C,S3的 Ki 值分别为200,2500,420,39,84,40 nM。
  • HY-B0451A
    Dopamine hydrochloride Agonist >98.0%
    Dopamine盐酸盐是多巴胺D1-5受体激动剂,是广泛存在于多种动物中的儿茶酚胺神经递质。
  • HY-14539
    Clozapine Inhibitor 99.97%
    Clozapine (HF 1854) 是用于治疗精神分裂症的抗精神病药。氯氮平是多巴胺和许多其他受体的有效拮抗剂,结合M1受体的Ki值为9.5 nM。
  • HY-14538
    Haloperidol Antagonist 99.72%
    Haloperidol 是有效的 dopamine D2 receptor 拮抗剂,为一种安定药。
  • HY-B0965
    Thioridazine hydrochloride Antagonist 99.93%
    Thioridazine是一种治疗精神类疾病的药物, 如精神分裂症, 具有多巴胺D4受体选择性和5-羟色胺拮抗作用。
  • HY-15296
    Cabergoline Agonist 99.47%
    Cabergoline 是一种麦角衍生的多巴胺 D2 亚类受体激动剂,高亲和力作用于 D2D35-HT2B 受体,Ki 分别为 0.7,1.5 和 1.2。
  • HY-12520A
    SKF 38393 hydrochloride Agonist
    SKF 38393盐酸盐是一种多巴胺D1受体激动剂, IC50为110 nM.
  • HY-B0532A
    Trifluoperazine dihydrochloride Inhibitor >99.0%
    Trifluoperazine双盐酸盐是多巴胺D2受体抑制剂,有抗精神病和止吐作用。
  • HY-12987
    Pimozide Antagonist 99.88%
    Pimozide 是 dopamine receptor 的拮抗剂,对 dopamine D2,D3 和 D1 受体的 Ki 值分别为 1.4 nM,2.5 nM 和 588 nM,同时对 α1-adrenoceptor 也有较高亲和性,Ki 值为 39 nM;Pimozide 也是 STAT3STAT5 的抑制剂。
  • HY-11018
    Risperidone Antagonist 99.16%
    Risperidone是 5-HT2 受体的阻断剂,P-糖蛋白 (P-Glycoprotein) 的抑制剂 和 dopamine D2 受体的拮抗剂,其对 5-HT2A 和 dopamine D2 受体的 Ki 值分别为 4.8,5.9 nM。
  • HY-B0411
    Domperidone Inhibitor 99.52%
    Domperidone是多巴胺受体阻断剂。
  • HY-15780
    Brexpiprazole Agonist 99.38%
    Brexpiprazole是人 5-HT1A多巴胺受体的部分激动剂,Ki分别为0.12 nM 和 0.3 nM。 Brexpiprazole也是 5-HT2A 受体的拮抗剂,Ki 为0.47 nM。
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