1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor

Dopamine Receptor

Dopamine Receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous ligand for dopamine receptors. Dopamine receptors are implicated in many neurological processes, including motivation, pleasure, cognition, memory, learning, and fine motor control, as well as modulation of neuroendocrine signaling. Abnormal dopamine receptor signaling and dopaminergic nerve function is implicated in several neuropsychiatric disorders. Thus, dopamine receptors are common neurologic drug targets; antipsychotics are often dopamine receptor antagonists while psychostimulants are typically indirect agonists of dopamine receptors. There are at least five subtypes of dopamine receptors, D1, D2, D3, D4, and D5. The D1 and D5 receptors are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4receptors are members of the D2-like family.

Dopamine Receptor 相关产品 (123):

Cat. No. Product Name Effect Purity
  • HY-B0407A
    Chlorpromazine hydrochloride Antagonist 99.83%
    Chlorpromazine Hydrochloride 是一种有效的 dopamine D2 受体,5-HT2A 受体,potassium channelsodium channel 的拮抗剂,抑制 D2 受体和 serotonin 5-HT2A 受体的活性,Ki 值分别为 363 nM 和 8.3 nM。
  • HY-B1081A
    Oxidopamine hydrobromide Activator >98.0%
    Oxidopamine hydrobromide是一个有选择性的含有儿茶酚胺的神经毒素,通过神经元的传输机制吸收和积累降低大脑儿茶酚胺水平。
  • HY-15780
    Brexpiprazole Agonist 99.38%
    Brexpiprazole 是一种有效的 人5-羟色胺(5-HT) 5-HT1A (Ki=0.12 nM) 和多巴胺 D2L (Ki=0.3 nM) 受体激动剂,且是 5-HT2A 受体拮抗剂(Ki=0.47 nM)。
  • HY-N0304
    L-DOPA Agonist 99.72%
    L-DOPA是DOPA的天然形式,是多巴胺前体,可作用于帕金森氏病。
  • HY-14539
    Clozapine Inhibitor 99.97%
    Clozapine (HF 1854) 是用于治疗精神分裂症的抗精神病药。氯氮平是多巴胺和许多其他受体的有效拮抗剂,结合M1受体的Ki值为9.5 nM。
  • HY-12987
    Pimozide Antagonist 98.01%
    Pimozide 是 dopamine receptor 的拮抗剂,对 dopamine D2,D3 和 D1 受体的 Ki 值分别为 1.4 nM,2.5 nM 和 588 nM,同时对 α1-adrenoceptor 也有较高亲和性,Ki 值为 39 nM;Pimozide 也是 STAT3STAT5 的抑制剂。
  • HY-10684
    Pridopidine Antagonist 99.76%
    Pridopidine 是一种多巴胺 (DA) 稳定剂,可用作一种低亲和力的多巴胺 D2 受体 (D2R) 拮抗剂。Pridopidine 高亲和力作用于 sigma 1受体 (S1R),Ki 值为 70 到 80 nM,比其对 D2R 的亲和力高约 100 倍。
  • HY-100143
    Pentiapine Inhibitor
    Pentiapine 是一种新型的多巴胺释放抑制剂。
  • HY-14538
    Haloperidol Antagonist 99.72%
    Haloperidol 是有效的 dopamine D2 receptor 拮抗剂,为一种安定药。
  • HY-19545A
    SCH 23390 hydrochloride Antagonist 99.31%
    SCH 23390 hydrochloride是有效的多巴胺受体D1拮抗剂,对D1和D5的Ki值分别为0.2和0.3 nM。
  • HY-15296
    Cabergoline Inhibitor 99.47%
    Cabergoline 是一种麦角衍生的多巴胺 D2 亚类受体激动剂,高亲和力作用于 D2D35-HT2B 受体,Ki 分别为 0.7,1.5 和 1.2。
  • HY-B0451A
    Dopamine hydrochloride Agonist >98.0%
    Dopamine盐酸盐是多巴胺D1-5受体激动剂,是广泛存在于多种动物中的儿茶酚胺神经递质。
  • HY-14763
    Cariprazine Modulator 98.01%
    Cariprazine 是一种新型的抗精神病试剂,高亲和力作用于 D3 (Ki=0.085 nM) 和 D2 (Ki=0.49 nM) 受体,稍低亲和力作用于 5-HT1A 受体 (Ki=2.6 nM)。
  • HY-12705A
    Bromocriptine mesylate Agonist 99.79%
    Bromocriptine mesylate 是一种有效的多巴胺 D2/D3 受体激动剂,结合多巴胺 D2 受体,pKi 为 8.05±0.2。
  • HY-14763A
    Cariprazine hydrochloride Modulator 99.89%
    Cariprazine(RGH188)盐酸盐有抗精神病活性,对D3和D2受体有较高亲和力,Ki分别为0.09 nM和0.5 nM,对5-HT(1A)受体有一定亲和力。
  • HY-B0411
    Domperidone Inhibitor 99.52%
    Domperidone是多巴胺受体阻断剂。
  • HY-11018
    Risperidone Antagonist 99.16%
    Risperidone(R64766)是5-HT2受体阻断剂和多巴胺D2受体拮抗剂,Ki值分别为0.16和1.4nM。
  • HY-B0965
    Thioridazine hydrochloride Antagonist 99.93%
    Thioridazine是一种治疗精神类疾病的药物, 如精神分裂症, 具有多巴胺D4受体选择性和5-羟色胺拮抗作用。
  • HY-A0008
    B-HT 920 Agonist 99.99%
    B-HT 920(Talipexole 2Hcl)是多巴胺D2受体和α2-肾上腺素受体激动剂,5-HT3受体拮抗剂,有抗帕金森病活性。
  • HY-B0532A
    Trifluoperazine dihydrochloride Inhibitor >99.0%
    Trifluoperazine双盐酸盐是多巴胺D2受体抑制剂,有抗精神病和止吐作用。
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