1. JAK/STAT Signaling
    Protein Tyrosine Kinase/RTK
  2. EGFR

EGFR

The EGFR family of receptor tyrosine kinases (RTK) comprises four distinct receptors: the EGFR (also known as ErbB-1/HER1), ErbB-2 (neu, HER2), ErbB-3 (HER3) and ErbB-4 (HER4). All EGFR family members are characterized by a modular structure consisting of an extracellular ligand-binding domain, a single hydrophobic transmembrane region, and the intracellular part harbouring the highly conserved tyrosine kinase domain. The ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including proliferation, differentiation, cell motility, and survival. Ten growth factors and their ErbB specificities are: EGF, amphiregulin (AR), and TGF bind ErbB-1; betacellulin, heparin binding EGF-like growth factor, and epiregulin bind both ErbB-1 and ErbB-4; the neuregulins (also called heregulins and Neu differentiation factors) NRG-1 and NRG-2 bind ErbB-3 and ErbB-4; and NRG-3 and NRG-4 bind ErbB-4. No known ligand binds ErbB-2. The three best characterized signaling pathways induced through ErbBs are Ras–mitogen-activated protein kinase (Ras-MAPK), phosphatidylinositol 3_ kinase-protein kinase B (PI3K-PKB/Akt), and phospholipase C–protein kinase C (PLC-PKC) pathways.

EGFR Isoform Specific Products:

  • EGFR/ErbB1/HER1

  • ErbB2/HER2

  • ErbB3/HER3

  • ErbB4/HER4

EGFR 相关产品 (88):

Cat. No. Product Name Effect Purity
  • HY-15772
    AZD-9291 Inhibitor 99.95%
    AZD-9291是不可逆的突变体选择性 EGFR 抑制剂;对EGFRL858R 和EGFRL858R/T790MIC50 值分别为12 和 1 nM。
  • HY-50895
    Gefitinib Inhibitor 99.89%
    Gefitinib 是一种有效的表皮生长因子受体 (EGFR) 抑制剂,在 NR6wtEGFR 细胞中,IC50 值为 2-37 nM。
  • HY-50896
    Erlotinib Inhibitor 99.82%
    Erlotinib 抑制纯化的 EGFR 激酶,IC50 为 2 nM。
  • HY-10261
    Afatinib Inhibitor 99.58%
    Afatinib 是一种不可逆的 EGFR/HER2 双重抑制剂,对 EGFRwt,EGFRL858R,EGFRL858R/T790M 都具有抑制作用,IC50 值分别为 0.5 nM,0.4 nM,10 nM 和 14 nM。
  • HY-50898
    Lapatinib Inhibitor 99.90%
    Lapatinib 是有效的 EGFRErbB2 抑制剂,IC50 分别为 10.2 和 9.8 nM。
  • HY-100499
    Tyrphostin AG 528 Inhibitor >98.0%
    Tyrphostin AG 528 是 EGFRErbB2 的抑制剂,其 IC50 值分别为 4.9 和 2.1 μM。
  • HY-12000
    AG-490 Inhibitor 98.93%
    AG-490 是一种酪氨酸激酶抑制剂,抑制 EGFRStat-3
  • HY-12008
    Erlotinib Hydrochloride Inhibitor 99.93%
    Erlotinib hydrochloride 抑制纯化的 EGFR 激酶,IC50 为 2 nM。
  • HY-32721
    Neratinib Inhibitor 98.84%
    Neratinib 是一种可口服的,不可逆的 tyrosine kinase 抑制剂,能够抑制 HER2 和 EGFR 的活性,IC50 值分别为 59 nM 和 92 nM。
  • HY-14596
    Genistein Inhibitor 99.64%
    Genistein 是一种有效的蛋白酪氨酸激酶 (PTK) 抑制剂,抑制 EGFRIC50 为 0.7 μg/mL (0.6 μM)。
  • HY-15772A
    AZD-9291 mesylate Inhibitor 99.94%
    AZD-9291 mesylate是不可逆的突变体选择性 EGFR 抑制剂;对EGFRL858R 和EGFRL858R/T790MIC50 值分别为12 和 1 nM。
  • HY-13524
    AG-1478 Inhibitor 99.74%
    AG-1478 是一种选择性的 EGFR 酪氨酸激酶抑制剂,IC50 为 3 nM。
  • HY-13653
    (-)-Epigallocatechin Gallate Inhibitor 99.60%
    (-)-Epigallocatechin Gallate 是一种天然的多酚黄酮类化合物,能够抑制 EGFRHER2HER3 的活化,具有抗肿瘤活性。
  • HY-13272
    Dacomitinib Inhibitor 99.91%
    Dacomitinib 是一种特异性的不可逆抑制剂 ERBB 家族抑制剂,作用于 EGFRERBB2ERBB4IC50 分别为 6 nM,45.7 nM 和 73.7 nM。
  • HY-19730
    Olmutinib Inhibitor 99.95%
    Olmutinib (HM61713; BI-1482694)是表皮生长因子受体 (EGFR) 酪氨酸激酶抑制剂, 在HCC827和H1975细胞中的IC50值分别为9.2 nM和10 nM。
  • HY-16069
    Irbinitinib Inhibitor 98.53%
    Irbinitinib (ARRY-380; ONT-380)是高效的选择性的HER2抑制剂,IC50值为8 nM。
  • HY-10261A
    Afatinib dimaleate Inhibitor 99.31%
    Afatinib dimaleate 是一种不可逆的 EGFR/HER2 抑制剂,有效作用于野生型和突变型 EGFR 和 HER2,作用于 EGFRwt,EGFRL858R,EGFRL858R/T790M 和 HER2,IC50 分别为 0.5 nM,0.4 nM,10 nM 和 14 nM。
  • HY-P9907
    Trastuzumab Inhibitor 99.30%
    Trastuzumab 是一种人源化单克隆抗体,其以高亲和力与 HER2 选择性结合。Trastuzumab 已被批准用于治疗 HER2 阳性转移性乳腺癌和 HER2 阳性胃癌。
  • HY-13314
    XL-647 Inhibitor 99.21%
    XL-647 (Tesevatinib;XL-647;KD-019) 是口服可用的多靶点酪氨酸激酶抑制剂; 抑制EGFRErbB2KDRFlt4EphB4 激酶活性的 IC50 值分别为0.3,16,1.5,8.7,和1.4 nM。
  • HY-50895A
    Gefitinib hydrochloride Inhibitor 99.33%
    Gefitinib hydrochloride 是一种有效的 EGFR tyrosine kinase 抑制剂,在 NR6wtEGFR 细胞中,IC50 值为 2-37 nM。
Isoform Specific Products

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