1. JAK/STAT Signaling
    Protein Tyrosine Kinase/RTK
  2. EGFR

EGFR

The EGFR family of receptor tyrosine kinases (RTK) comprises four distinct receptors: the EGFR (also known as ErbB-1/HER1), ErbB-2 (neu, HER2), ErbB-3 (HER3) and ErbB-4 (HER4). All EGFR family members are characterized by a modular structure consisting of an extracellular ligand-binding domain, a single hydrophobic transmembrane region, and the intracellular part harbouring the highly conserved tyrosine kinase domain. The ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including proliferation, differentiation, cell motility, and survival. Ten growth factors and their ErbB specificities are: EGF, amphiregulin (AR), and TGF bind ErbB-1; betacellulin, heparin binding EGF-like growth factor, and epiregulin bind both ErbB-1 and ErbB-4; the neuregulins (also called heregulins and Neu differentiation factors) NRG-1 and NRG-2 bind ErbB-3 and ErbB-4; and NRG-3 and NRG-4 bind ErbB-4. No known ligand binds ErbB-2. The three best characterized signaling pathways induced through ErbBs are Ras–mitogen-activated protein kinase (Ras-MAPK), phosphatidylinositol 3_ kinase-protein kinase B (PI3K-PKB/Akt), and phospholipase C–protein kinase C (PLC-PKC) pathways.

EGFR Isoform Specific Products:

  • EGFR/ErbB1/HER1

  • ErbB2/HER2

  • ErbB3/HER3

  • ErbB4/HER4

EGFR 相关产品 (98):

Cat. No. Product Name Effect Purity
  • HY-15772
    Osimertinib Inhibitor 99.95%
    Osimertinib (AZD-9291) 是一种不可逆和突变的选择性的 EGFR 抑制剂,抑制EGFRL858R 和EGFRL858R/T790MIC50 分别为12 和 1 nM。
  • HY-50895
    Gefitinib Inhibitor 99.89%
    Gefitinib 是一种有效的表皮生长因子受体 (EGFR) 抑制剂,在 NR6wtEGFR 细胞中 IC50 值为 2-37 nM。
  • HY-10261
    Afatinib Inhibitor 99.99%
    Afatinib (BIBW 2992) 是不可逆的 EGFR 家族抑制剂,抑制EGFRwt,EGFRL858R,EGFRL858R/T790M 和 HER2的 IC50 分别为0.5 nM,0.4 nM,10 nM 和 14 nM。
  • HY-50896
    Erlotinib Inhibitor 99.99%
    Erlotinib是一种治疗非小细胞肺癌的药物。抑制纯化 EGFR 激酶的 IC50 为2 nM。
  • HY-12000
    AG-490 Inhibitor 99.84%
    AG-490是酪氨酸激酶抑制剂,其抑制EGFRStat-3JAK2/3
  • HY-112299
    TAS6417 Inhibitor 99.55%
    TAS6417 是表皮生长因子受体 (EGFR) 的抑制剂,也是治疗非小细胞肺癌的有效候选药物,其 IC50 值为 1.1-8.0 nM。
  • HY-112823B
    HS-10296 hydrochloride Inhibitor 98.05%
    HS-10296 hydrochloride是具有口服活性的、表皮生长因子受体 (EGFR) 激活突变体和 T790M 耐药性突变体的第三代抑制剂,对野生型EGFR活性有限。
  • HY-112870A
    AST2818 mesylate Inhibitor 99.99%
    AST2818 mesylate 是一种 EGFR 抑制剂。
  • HY-50898
    Lapatinib Inhibitor 99.83%
    Lapatinib (GW572016)是有效的 EGFRErbB2 抑制剂,IC50 分别为10.2 和 9.8 nM。
  • HY-32721
    Neratinib Inhibitor 98.84%
    Neratinib 是一种可口服的,不可逆的 tyrosine kinase 抑制剂,能够抑制 HER2 和 EGFR 的活性,IC50 值分别为 59 nM 和 92 nM。
  • HY-P9907
    Trastuzumab Inhibitor 99.30%
    Trastuzumab 是一种人源化单克隆抗体,其以高亲和力与 HER2 选择性结合。Trastuzumab 已被批准用于治疗 HER2 阳性转移性乳腺癌和 HER2 阳性胃癌。
  • HY-14596
    Genistein Inhibitor 99.64%
    Genistein是一种大豆异黄酮,是一种多重的酪氨酸激酶 (tyrosine kinases) 抑制剂,是对多种癌症的化疗剂,主要通过改变细胞凋亡,细胞周期和血管生成以及抑制转移。
  • HY-12008
    Erlotinib Hydrochloride Inhibitor 99.93%
    Erlotinib 抑制 EGFR 激酶的 IC50 为 2 nM。
  • HY-13653
    (-)-Epigallocatechin Gallate Inhibitor 99.60%
    (-)-Epigallocatechin Gallate 是一种天然的多酚黄酮类化合物,能够抑制 EGFRHER2HER3 的活化,具有抗肿瘤活性。
  • HY-13524
    AG-1478 Inhibitor 99.74%
    AG-1478 是一种选择性的 EGFR 酪氨酸激酶抑制剂,IC50 为 3 nM。
  • HY-P9905
    Cetuximab Inhibitor 99.60%
    Cetuximab 是一种单克隆抗体,能够抑制 EGFR,SPR 方法测得 Cetuximab 对可溶性 EGFRKd 值为 0.201 nM;Cetuximab 具有高效的抗肿瘤作用。
  • HY-13272
    Dacomitinib Inhibitor 99.83%
    Dacomitinib 是一种特异,不可逆的 ERBB 家族抑制剂,作用于 EGFRERBB2ERBB4IC50 分别为 6 nM,45.7 nM 和 73.7 nM。
  • HY-15772A
    Osimertinib mesylate Inhibitor 99.94%
    Osimertinib mesylate (AZD-9291 mesylate) 是不可逆的突变体选择性 EGFR 抑制剂;对EGFRL858R 和EGFRL858R/T790MIC50 值分别为12 和 1 nM。
  • HY-15730
    Poziotinib Inhibitor 99.92%
    Poziotinib(NOV120101; HM781-36B)是pan-HER激酶不可逆抑制剂,对HER1/HER2/HER4的IC50值分别为3/5/23nM。
  • HY-16069
    Tucatinib Inhibitor 98.53%
    Tucatinib (Irbinitinib; ARRY-380; ONT-380) 是有效,选择性的 HER2 抑制剂,IC50 为8 nM。
Isoform Specific Products

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Sorry. There is currently no product that acts on isoform together.

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