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Estrogen Receptor/ERR

Estrogen receptors are a group of proteins found inside cells. They are receptors that are activated by the hormone estrogen (17β-estradiol). Two classes of estrogen receptor exist: ER, which is a member of the nuclear hormone family of intracellular receptors, and GPER (GPR30), which is a member of the rhodopsin-like family of G protein-coupled receptors. The ER's helix 12 domain plays a crucial role in determining interactions with coactivators and corepressors and, therefore, the respective agonist or antagonist effect of the ligand. Different ligands may differ in their affinity for alpha and beta isoforms of the estrogen receptor: estradiol binds equally well to both receptors, estrone, and raloxifene bind preferentially to the alpha receptor, estriol, and genistein to the beta receptor. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined.

Estrogen Receptor/ERR 相关产品 (65):

Cat. No. Product Name Effect Purity
  • HY-13757A
    Tamoxifen Inhibitor 99.46%
    Tamoxifen 是一种抗雌激素,抑制雌激素结合到雌激素受体 (estrogen receptors)。
  • HY-13636
    Fulvestrant Inhibitor 99.89%
    Fulvestrant 是一种有效的特异性雌激素作用抑制剂,作用于雌激素受体 (Estrogen Receptor),IC50 为 9.4 nM。
  • HY-B0141
    Estradiol Agonist 98.45%
    Estradiol 是人体主要的甾体类雌激素。
  • HY-12870
    AZD9496 Antagonist 99.55%
    AZD9496 是一种有效的选择性雌激素受体 (ERα)拮抗剂,IC50 为 0.28 nM。
  • HY-13757
    Tamoxifen Citrate Inhibitor 99.87%
    Tamoxifen Citrate 是一种抗雌激素,抑制雌激素结合到雌激素受体 (estrogen receptors)。
  • HY-14589
    Chrysin Inhibitor 99.22%
    Chrysin 是一种雌激素阻断剂。
  • HY-103456
    PHTPP Antagonist 99.07%
    PHTPP 是一种选择性的 ERβ 拮抗剂。
  • HY-100583
    (-)-(S)-Equol 99.82%
    (-)-(S)-Equol是雌激素受体β (estrogen receptor β) 的高亲和力配体。
  • HY-19822A
    Elacestrant dihydrochloride Inhibitor 98.93%
    Elacestrant dihydrochloride (RAD1901 dihydrochloride) 是有选择性和口服活性的雌激素受体 (ERR)的降解剂,对ERα和ERβ的IC50值分别为48和870 nM.
  • HY-14590
    Kaempferol Inhibitor 99.47%
    Kaempferol 在乳腺癌细胞中抑制雌激素受体 (estrogen receptor α) 表达,在胶质母细胞瘤细胞和肺癌细胞中,通过激活 MEK-MAPK 诱导细胞凋亡。
  • HY-12864
    GDC-0810 Inhibitor 99.87%
    GDC-0810 是一种可口服的,选择性的雌激素降能器 (selective estrogen receptor degrader),IC50 值为 0.7 nM。
  • HY-10426
    XCT790 Agonist 98.01%
  • HY-A0036
    Bazedoxifene acetate Modulator 99.93%
    Bazedoxifene acetate (TSE 424; WAY-TES 424)是新型雌激素受体调节剂(SERM)。
  • HY-13738A
    Raloxifene hydrochloride Antagonist 99.64%
  • HY-A0038
    Lasofoxifene Tartrate Modulator 99.91%
    Lasofoxifene酒石酸盐是一种非甾体类的选择性雌激素受体调节剂 (SERM)。
  • HY-B0005
    Toremifene Citrate Modulator 99.59%
    Toremifene(NK 622; FC 1157a)柠檬酸盐是第二代选择性雌激素受体调节剂,对雌激素受体的IC50为1μM。
  • HY-18719A
    Endoxifen Z-isomer hydrochloride Inhibitor 99.31%
    Endoxifen Z-isomer hydrochloride盐酸盐是最重要的Tamoxifen代谢产物, 诱导在表达ERα的乳腺癌细胞中发挥抗雌激素作用, Endoxifen抑制hERG, 这种作用具有浓度依赖性, IC50值为1.6μM。
  • HY-N0322
    Cholesterol Agonist 98.00%
    胆固醇 (Cholesterol) 是哺乳动物中主要的甾体类化合物,在基本的细胞生命活动中起到重要作用。
  • HY-N0835
    (20S)-Protopanaxatriol Modulator >98.0%
  • HY-B1100
    Estradiol cypionate Inhibitor >98.0%
    Estradiol cypionate 是Estradiol的 17β-环戊丙酸酯, 通过作用于雌激素受体而抑制ET-1合成。