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Estrogen Receptor/ERR

Estrogen receptors are a group of proteins found inside cells. They are receptors that are activated by the hormone estrogen (17β-estradiol). Two classes of estrogen receptor exist: ER, which is a member of the nuclear hormone family of intracellular receptors, and GPER (GPR30), which is a member of the rhodopsin-like family of G protein-coupled receptors. The ER's helix 12 domain plays a crucial role in determining interactions with coactivators and corepressors and, therefore, the respective agonist or antagonist effect of the ligand. Different ligands may differ in their affinity for alpha and beta isoforms of the estrogen receptor: estradiol binds equally well to both receptors, estrone, and raloxifene bind preferentially to the alpha receptor, estriol, and genistein to the beta receptor. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined.

Estrogen Receptor/ERR 相关产品 (80):

Cat. No. Product Name Effect Purity
  • HY-13757A
    Tamoxifen Modulator 99.76%
    Tamoxifen 是一种抗雌激素,抑制雌激素结合到雌激素受体 (estrogen receptors)。
  • HY-13636
    Fulvestrant Inhibitor 99.89%
    Fulvestrant 是一种有效的特异性雌激素作用抑制剂,作用于雌激素受体 (Estrogen Receptor),IC50 为 9.4 nM。
  • HY-B0141
    Estradiol Agonist 98.45%
    Estradiol 是人体主要的甾体类雌激素。
  • HY-16950
    4-Hydroxytamoxifen Antagonist 99.27%
    4-Hydroxytamoxifen 是 tamoxifen 的有效代谢物,为选择性的 estrogen receptor 拮抗剂,能够抑制 [3H]oestradiol 与雌激素受体结合,IC50 值为 3.3 nM,同时可增强 CRISPR/Cas9 的活性;4-Hydroxytamoxifen 广泛用于乳腺癌的研究。
  • HY-19822A
    Elacestrant dihydrochloride Inhibitor 98.93%
    Elacestrant dihydrochloride (RAD1901 dihydrochloride) 是有选择性和口服活性的雌激素受体 (ERR)的降解剂,对ERα和ERβ的IC50值分别为48和870 nM.
  • HY-N0250
    Saikosaponin D Activator >98.0%
    Saikosaponin D 是从柴胡中分离到的三萜皂苷类,具有抗炎,抗菌,抗肿瘤,抗过敏的功效;Saikosaponin D 可以抑制 selectinSTAT3NF-kB 的活性,活化 estrogen receptor-β
  • HY-111486
    LSZ-102 Inhibitor
    LSZ-102 是一种强效, 口服生物有效的选择性雌激素受体降解剂, 其 IC50 值为 0.2 nM。
  • HY-111484
    GDC-0927 Antagonist
    GDC-0927 是一种新型, 强效, 非甾体类且口服生物可利用的选择性雌激素受体拮抗剂。
  • HY-13757
    Tamoxifen Citrate Inhibitor >99.0%
    Tamoxifen Citrate 是一种抗雌激素,抑制雌激素结合到雌激素受体 (estrogen receptors)。
  • HY-12870
    AZD9496 Antagonist 99.15%
    AZD9496 是一种有效的选择性雌激素受体 (ERα)拮抗剂,IC50 为 0.28 nM。
  • HY-14590
    Kaempferol Inhibitor 99.47%
    Kaempferol 在乳腺癌细胞中抑制雌激素受体 (estrogen receptor α) 表达,在胶质母细胞瘤细胞和肺癌细胞中,通过激活 MEK-MAPK 诱导细胞凋亡。
  • HY-10426
    XCT790 Agonist 98.01%
  • HY-12864
    GDC-0810 Inhibitor 99.87%
    GDC-0810 是一种可口服的,选择性的雌激素降能器 (selective estrogen receptor degrader),IC50 值为 0.7 nM。
  • HY-A0036
    Bazedoxifene acetate Modulator 99.93%
    Bazedoxifene acetate (TSE 424; WAY-TES 424)是新型雌激素受体调节剂(SERM)。
  • HY-13738A
    Raloxifene hydrochloride Antagonist 99.64%
  • HY-N0835
    (20S)-Protopanaxatriol Agonist >98.0%
    (20S)-Protopanaxatriol 是人参皂苷的代谢物,通过 glucocorticoid receptoroestrogen receptor 起作用,同时为 LXRα 的抑制剂, PPARγ 的激活剂。
  • HY-100583
    (-)-(S)-Equol 99.82%
    (-)-(S)-Equol是雌激素受体β (estrogen receptor β) 的高亲和力配体。
  • HY-B0234
    Estrone Agonist 99.86%
  • HY-103456
    PHTPP Antagonist 99.07%
    PHTPP 是一种选择性的 ERβ 拮抗剂。
  • HY-N2371
    27-Hydroxycholesterol Modulator 99.20%
    27-Hydroxycholesterol是选择性的雌激素受体 (estrogen receptor) 调节剂和肝X 受体 (liver X receptor) 激动剂。
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