1. Apoptosis
  2. Ferroptosis

Ferroptosis

Ferroptosis is a non-apoptotic form of regulated cell death. It is distinct from other regulated cell death phenotypes, such as apoptosis and necroptosis. Ferroptosis is characterized by extensive lipid peroxidation, which can be suppressed by iron chelators or lipophilic antioxidants. Mechanistically, Ferroptosis inducers are divided into two classes: (1) inhibitors of cystine import via system xc (e.g., Erastin), which subsequently causes depletion of glutathione (GSH), and (2) covalent inhibitors (e.g., (1S, 3R)-RSL3) of glutathione peroxidase 4 (GPX4). Since GPX4 reduces lipid hydroperoxides using GSH as a co-substrate, both compound classes ultimately result in loss of GPX4 activity, followed by elevated levels of lipid reactive oxygen species (ROS) and consequent cell death.

Ferroptosis is an iron- and ROS-dependent form of regulated cell death (RCD). Misregulated Ferroptosis has been implicated in multiple physiological and pathological processes, including cancer cell death, neurotoxicity, neurodegenerative diseases, acute renal failure, drug-induced hepatotoxicity, hepatic and heart ischemia/reperfusion injury, and T-cell immunity.

Ferroptosis 相关产品 (5):

Cat. No. Product Name Effect Purity
  • HY-15763
    Erastin Activator 99.54%
    Erastin是铁诱导的细胞死亡激活剂。
  • HY-12726
    Liproxstatin-1 Inhibitor 98.38%
    Liproxstatin-1 是一种有效的 ferroptosis 抑制剂,IC50 值约为 38 nM。
  • HY-100887
    Piperazine Erastin Activator 98.25%
    Piperazine erastin是erastin的类似物,其诱导铁离子依赖形式的非凋亡性细胞死亡,称为铁死亡。
  • HY-100579
    Ferrostatin-1 Inhibitor 98.70%
    Ferrostatin-1 是 ferroptosis 的强效抑制剂,其 EC50 值为 60 nM。
  • HY-103087
    FIN56 Activator 98.03%
    FIN56 是一种特异性的铁死亡诱导剂。