1. GPCR/G Protein
  2. Glucagon Receptor

Glucagon Receptor

Glucagon receptor is in the G protein-coupled receptor family, that is important in controlling blood glucose levels. The glucagon receptor is a 62 kDa protein that is activated by glucagon and is a member of the class B G-protein coupled family of receptors, coupled to G alpha i, Gs and to a lesser extent G alpha q. Stimulation of the receptor results in activation of adenylate cyclase and increased levels of intracellular cAMP. In humans, the glucagon receptor is encoded by the GCGR gene. Glucagon receptors are mainly expressed in liver and in kidney with lesser amounts found in heart, adipose tissue, spleen, thymus, adrenal glands, pancreas, cerebral cortex, and gastrointestinal tract.

Glucagon Receptor 相关产品 (15):

Cat. No. Product Name Effect Purity
  • HY-13443
    Exendin-4 Activator 98.96%
    Exendin-4是由39个氨基酸组成的多肽。它是长效的glucagon-like peptide-1受体激动剂,IC50值为3.22 nM。
  • HY-P0014
    Liraglutide Agonist 99.96%
    Liraglutide是一种胰高血糖素样肽-1 (GLP-1)受体激动剂,用于治疗2型糖尿病。
  • HY-50663
    MK 0893 Antagonist 99.47%
    MK 0893 是一种有效的,选择性的 glucagon receptor 拮抗剂,IC50 值为 6.6 nM,选择性是对 GIPR,PAC1,GLP-1R,VPAC1 和 VPAC2 的 200 多倍。
  • HY-19904
    Adomeglivant Antagonist 99.55%
  • HY-50158
    glucagon receptor antagonists-2 Antagonist
    Glucagon receptor antagonists-2是高活性高血糖素受体拮抗剂。
  • HY-P0055
    GLP-17-37 Inhibitor 98.62%
  • HY-13443A
    Exendin-4 Acetate Activator 98.69%
    Exendin-4 acetate是由39个氨基酸组成的多肽。它是长效的glucagon-like peptide-1受体激动剂,IC50值为3.22 nM。
  • HY-P0165
    Taspoglutide Agonist
    Taspoglutide是为治疗2型糖尿病而开发的长效GLP-1受体激动剂, EC50值为0.06 nM。
  • HY-19947
    glucagon receptor antagonists-4 Antagonist
    glucagon receptor antagonists-4是一个高度有效的胰高血糖素受体拮抗剂。
  • HY-P0119
    Lixisenatide Inhibitor 98.36%
    Lixisenatide抑制glucagon的释放,能有效的减少postprandial glucago, 在糖尿病治疗中有促进作用。
  • HY-10036
    glucagon receptor antagonists-1 Antagonist
    Glucagon receptor antagonists-1是高活性高血糖素受体拮抗剂。
  • HY-50159
    glucagon receptor antagonists-3 Antagonist
    Glucagon receptor antagonists-3是高活性高血糖素受体拮抗剂。
  • HY-12525
    LGD-6972 Antagonist >98.0%
  • HY-50675
    GRA Ex-25 Inhibitor 99.12%
    GRA Ex-25 是一种 glucagon 受体的抑制剂,抑制大鼠和人的 glucagon 受体,IC50 值分别为 56 和 55 nM。
  • HY-P0264
    Exendin 9-39 Antagonist
    Exendin (9-39) 是特异竞争性的 glucagon-like peptide-1 受体激动剂。