1. GPCR/G Protein
  2. Glucagon Receptor

Glucagon Receptor

Glucagon receptor is in the G protein-coupled receptor family, that is important in controlling blood glucose levels. The glucagon receptor is a 62 kDa protein that is activated by glucagon and is a member of the class B G-protein coupled family of receptors, coupled to G alpha i, Gs and to a lesser extent G alpha q. Stimulation of the receptor results in activation of adenylate cyclase and increased levels of intracellular cAMP. In humans, the glucagon receptor is encoded by the GCGR gene. Glucagon receptors are mainly expressed in liver and in kidney with lesser amounts found in heart, adipose tissue, spleen, thymus, adrenal glands, pancreas, cerebral cortex, and gastrointestinal tract.

Glucagon Receptor 相关产品 (33):

Cat. No. Product Name Effect Purity
  • HY-13443
    Exendin-4 Activator 98.96%
    Exendin-4 acetate是由39个氨基酸组成的多肽。它是长效的glucagon-like peptide-1受体激动剂,IC50值为3.22 nM。
  • HY-P0014
    Liraglutide Agonist 99.96%
    Liraglutide 是一种胰高血糖素样肽-1 (GLP-1) 受体激动剂,用于治疗 2 型糖尿病。
  • HY-P0082
    Glucagon
    Glucagon是一种多肽激素,有助于调节体内的血糖(葡萄糖)水平。
  • HY-19904
    Adomeglivant Antagonist 99.55%
    Adomeglivant是一个强的,有选择性的胰高血糖素受体拮抗剂。
  • HY-P0264
    Exendin 9-39 Antagonist
    Exendin (9-39) 是特异竞争性的 glucagon-like peptide-1 受体拮抗剂。
  • HY-112679
    GLP-1 receptor agonist-1 Agonist 99.15%
    GLP-1 receptor agonist-1 是胰高血糖素样肽受体 (GLP-1R) 的激动剂。
  • HY-112185
    GLP-1 receptor agonist 1 Agonist
    GLP-1 receptor agonist 1 是一种胰高血糖素样肽 (GLP-1) 受体激动剂,详细信息请参考专利文献 WO2018056453A1 中的化合物 67。
  • HY-114118
    Semaglutide Agonist
    Semaglutide是人胰高血糖素样肽-1 的一个长效类似物, 是人胰高血糖素样肽-1 (GLP-1) 受体的激动剂,临床上可用于治疗2 型糖尿病。
  • HY-50663
    MK 0893 Antagonist 99.22%
    MK 0893 是一种有效的,选择性的 glucagon receptor 拮抗剂,IC50 值为 6.6 nM,选择性是对 GIPR,PAC1,GLP-1R,VPAC1 和 VPAC2 的 200 多倍。
  • HY-13443A
    Exendin-4 Acetate Activator 98.69%
    Exendin-4 acetate是由39个氨基酸组成的多肽。它是长效的glucagon-like peptide-1受体激动剂,IC50值为3.22 nM。
  • HY-P0054
    GLP-1(7-36) Acetate 98.42%
    GLP-1(7-36) Acetate 是一种主要的肠道激素,在葡萄糖的刺激下,它能促使胰岛 β 细胞分泌胰岛素。
  • HY-P0119
    Lixisenatide Inhibitor 98.36%
    Lixisenatide 是胰高血糖素样肽 1 受体 (GLP-1R) 的激动剂,可用于治疗 2 型糖尿病。
  • HY-P0055
    GLP-1(7-37) 98.62%
    GLP-1(7-37) 是一种肠道胰岛素激素,可以增强葡萄糖诱导的胰岛素分泌。
  • HY-12525
    LGD-6972 Antagonist >98.0%
    LGD-6972是一种胰高血糖素受体拮抗剂。
  • HY-P1348
    GLP-1 moiety from Dulaglutide
    GLP-1 moiety from Dulaglutide 是来源于 Dulaglitude 的具有 31 个氨基酸的片段, Dulaglitude 是胰高血糖素样肽 1 受体 (GLP-1) 激动剂, 来自专利 US 20160369010 A1。
  • HY-10036
    Glucagon receptor antagonists-1 Antagonist
    Glucagon receptor antagonists-1是高活性高血糖素受体拮抗剂。
  • HY-P0165
    Taspoglutide Agonist
    Taspoglutide是为治疗2型糖尿病而开发的长效GLP-1受体激动剂, EC50值为0.06 nM。
  • HY-50675
    GRA Ex-25 Inhibitor 99.12%
    GRA Ex-25 是一种 glucagon 受体的抑制剂,抑制大鼠和人的 glucagon 受体,IC50 值分别为 56 和 55 nM。
  • HY-P1231
    GTFTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPS 99.03%
    GTFTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPS是Exendin-4多肽衍生物。
  • HY-P1229
    FTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPS 98.01%
    FTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPS是Exendin-4多肽衍生物。
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