1. Metabolic Enzyme/Protease
  2. HIV Protease

HIV Protease

HIV Protease is a retroviral aspartyl protease that is essential for the life-cycle of HIV, the retrovirus that causes AIDS. HIV protease cleaves newly synthesized polyproteins at the appropriate places to create the mature protein components of an infectious HIV virion. Without effective HIV protease, HIV virions remain uninfectious. Thus, mutation of HIV protease's active site or inhibition of its activity disrupts HIV’s ability to replicate and infect additional cells, making HIV protease inhibition the subject of considerable pharmaceutical research. Mutations enable HIV to avoid treatments that involve only one drug, so there is growing use of multiple-drug therapies in which both a protease inhibitor AND a reverse transcript inhibitor are combined.

HIV Protease 相关产品 (20):

Cat. No. Product Name Effect Purity
  • HY-P0018
    Pepstatin Inhibitor >98.0%
    Pepstatin 是由放线菌类产生的一种特异性的天冬氨酸蛋白酶 (aspartic proteases) 抑制剂,能够抑制 hemoglobin-pepsin,hemoglobin-proctase,casein-pepsin,casein-proctase,casein-acid protease 和 hemoglobin-acid protease 的活性,IC50 值分别为 4.5 nM,6.2 nM,150 nM,290 nM,520 nM 和 260 nM;同时可抑制 HIV protease 的活性。
  • HY-90001
    Ritonavir Inhibitor 99.68%
    Ritonavir是用于治疗HIV感染和AIDS的 HIV蛋白酶的抑制剂。
  • HY-17367A
    Atazanavir sulfate Inhibitor 99.64%
    Atazanavir硫酸盐是HIV-1蛋白酶高活性抑制剂。
  • HY-P0018A
    Pepstatin Trifluoroacetate Inhibitor 99.11%
    Pepstatin Trifluoroacetate 是由放线菌类产生的一种特异性的天冬氨酸蛋白酶 (aspartic proteases) 抑制剂,能够抑制 hemoglobin-pepsin,hemoglobin-proctase,casein-pepsin,casein-proctase,casein-acid protease 和 hemoglobin-acid protease 的活性,IC50 值分别为 4.5 nM,6.2 nM,150 nM,290 nM,520 nM 和 260 nM;同时可抑制 HIV protease 的活性。
  • HY-15148
    Tipranavir Inhibitor 99.13%
    Tipranavir 有效抑制 HIV-1 蛋白酶 酶活性和二聚化,对抗多种蛋白酶抑制剂(PI)的HIV-1分离株具有有效的活性,IC50 为 66-410 nM。
  • HY-P0018B
    Pepstatin Ammonium Inhibitor 99.35%
    Pepstatin Ammonium 是由放线菌类产生的一种特异性的天冬氨酸蛋白酶 (aspartic proteases) 抑制剂,能够抑制 hemoglobin-pepsin,hemoglobin-proctase,casein-pepsin,casein-proctase,casein-acid protease 和 hemoglobin-acid protease 的活性,IC50 值分别为 4.5 nM,6.2 nM,150 nM,290 nM,520 nM 和 260 nM;同时可抑制 HIV protease 的活性。
  • HY-17007
    Saquinavir Inhibitor 99.91%
    Saquinavir(Ro 31-8959)是HIV蛋白酶抑制剂。
  • HY-15287A
    Nelfinavir Mesylate Inhibitor 98.90%
    Nelfinavir(AG-1341)是口服的人HIV-1蛋白酶抑制剂,Ki为2nM。
  • HY-14588
    Lopinavir Inhibitor 99.58%
    Lopinavir是高亲和性HIV蛋白酶抑制剂,Ki为1.3 pM。
  • HY-B0689A
    Indinavir sulfate Inhibitor 99.50%
    Indinavir(MK-639; L735524)硫酸盐是HIV蛋白酶抑制剂,具有很好的口服生物相容性。
  • HY-17041
    Darunavir Ethanolate Inhibitor 99.73%
    Darunavir ethanolate (TMC114 ethanolate) 是一种用于治疗和预防HIV/AIDS的HIV蛋白酶抑制剂。对野生型HIV-1蛋白酶的Ki值为1 nM。
  • HY-17040
    Darunavir Inhibitor 99.39%
    Darunavir(TMC114)是HIV蛋白酶抑制剂。
  • HY-17003
    Saquinavir Mesylate Inhibitor 99.79%
    Saquinavir甲磺酸盐是HIV蛋白酶抑制剂,用于逆转录病毒治疗。
  • HY-17430
    Amprenavir Inhibitor 99.61%
    Amprenavir (Agenerase)是HIV蛋白酶抑制剂,Ki为0.6 nM。
  • HY-15287
    Nelfinavir Inhibitor 98.16%
    Nelfinavir(AG-1341) is a potent and orally bioavailable human immunodeficiency virus HIV-1 protease inhibitor (Ki=2 nM) and is widely prescribed in combination with HIV reverse transcriptase inhibitors for the treatment of HIV infection.
  • HY-B0689
    Indinavir Inhibitor
    Indinavir(MK-639; L735524)是HIV蛋白酶抑制剂,具有很好的口服生物相容性。
  • HY-17367
    Atazanavir Inhibitor
    Atazanavir(BMS-232632)是HIV-1蛋白酶高活性抑制剂。
  • HY-19400
    DPC-681 Inhibitor
    DPC-681是一种有效的选择性HIV protease 抑制剂, 抑制野生型HIV-1IC90 值为4 - 40 nM。
  • HY-19236
    PNU-103017 Inhibitor
    PNU-103017 是一种 HIV 蛋白酶抑制剂。
  • HY-U00261
    L-689502 Inhibitor
    L-689502 是一个有效的 HIV-1 蛋白酶 (HIV-l protease) 抑制剂,其 IC50 值为 1 nM。
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