HOXA (同源框 A)

Homeobox A (HOXA) is a general term for the genes in cluster A of the Homeobox gene family. HOXA contains the homeobox sequence, which can encode the homeodomain and plays a key regulatory role in processes such as biological embryonic development and cell differentiation. During embryonic development, HOXA can regulate somite differentiation and the positioning of organ primordia, ensuring that all parts of the body develop in the correct pattern and sequence. HOXA is also of great significance for the maintenance of tissue morphology. In addition, HOXA is involved in the differentiation processes of hematopoietic cells, nerve cells, and so on. Abnormalities in HOXA genes are closely related to the occurrence and development of various diseases, including congenital diseases such as hand-foot-genital syndrome and neural tube defects like spina bifida, as well as multiple tumor diseases such as leukemia and breast cancer^[1][2].