1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Neprilysin

Neprilysin

Neprilysin (NEP) is a type II membrane metalloendopeptidase composed of ∼750 residues with an active site containing a zinc-binding motif (HEXXH) at the extracellular carboxyl terminal domain. Neprilysin is capable of degrading the monomeric and the oligomeric forms of Aβ peptide. Neprilysin is the dominant Aβ peptide-degrading enzyme in the brain; Neprilysin becomes inactivated and down-regulated during both the early stages of Alzheimer’s disease (AD) and aging.

Neprilysin is a neutral endopeptidase and its inhibition increases bioavailability of natriuretic peptides, bradykinin, and substance P, resulting in natriuretic, vasodilatatory, and anti-proliferative effects.

Neprilysin 相关产品 (11):

Cat. No. Product Name Effect Purity
  • HY-18204A
    LCZ696 Inhibitor 99.99%
    LCZ696 (Sacubitril mixture with Valsartan) 由 Valsartan 和 Sacubitril (AHU377) 以 1:1 的摩尔比组成,是一种口服生物有效的,双重作用的 angiotensin receptor-neprilysin 抑制剂,用于治疗高血压和心脏衰竭。
  • HY-17620
    Sacubitrilat Inhibitor 99.85%
    Sacubitrilat 是一种活性的脑啡肽酶 (NEP) 抑制剂。
  • HY-15407
    Sacubitril Inhibitor 99.71%
    Sacubitril (AHU-377) 是有效的NEP抑制剂,IC50值为5 nM。Sacubitril (AHU-377) 是治疗心力衰竭药物LCZ696的一个组分。
  • HY-N2021A
    Phosphoramidon Disodium Inhibitor >98.0%
    Phosphoramidon disodium 是金属蛋白酶 ( metalloprotease ) 抑制剂 。抑制内皮素转化酶 ( ECE ) ,中性肽内切酶 ( NEP ) 和血管紧张素转换酶 ( ACE ) 的IC50 值分别为 3.5 ,0.034 和 78 μM。
  • HY-15407A
    Sacubitril hemicalcium salt Inhibitor 99.64%
    Sacubitril hemicalcium salt (AHU-377 hemicalcium salt) 是有效的NEP抑制剂,IC50值为5 nM。AHU-377是治疗心力衰竭药物LCZ696的一个组分。
  • HY-114412
    TD-0212 Inhibitor
    TD-0212 (compound 35) 是一种具有口服活性的、血管紧张素II型1受体 AT1 和脑啡肽酶 (NEP)的双抑制剂,其对 AT1pKi 值为 8.9, 对 NEP 的pIC50值为9.2。
  • HY-17399
    Racecadotril Inhibitor >98.0%
    Racecadotril (acetorphan)是脑啡肽酶抑制剂,IC50为4.5 uM,能抑制内源的脑啡肽降解。
  • HY-U00171
    SQ28603 Inhibitor
    SQ28603 是一种有效的选择性中性内肽酶 3.4.24.11 (NEP) 抑制剂。
  • HY-U00294
    NEP-In-1 Inhibitor
    NEP-IN-1 是一种中性肽链内切酶 (NEP) 抑制剂,抑制 dNEP, IC50 为 2 nM。
  • HY-19649
    Candoxatril Inhibitor
    Candoxatril 是中性肽链内切酶 (NEP) 的一个抑制剂。
  • HY-U00336
    NEP-IN-2 Inhibitor
    NEP-IN-2 是一种 neutral endopeptidase 抑制剂,主要用于研究动脉粥样硬化、再狭窄症的扩散等症状。
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