1. GPCR/G Protein
  2. P2Y Receptor

P2Y Receptor

P2Y receptors are a family of purinergic G protein-coupled receptors, stimulated by nucleotides such as ATP, ADP, UTP, UDP and UDP-glucose. To date, 12 P2Y receptors have been cloned in humans: P2Y1, P2Y2, P2Y4, P2Y5, P2Y6, P2Y8, P2Y9, P2Y10, P2Y11, P2Y12, P2Y13 and P2Y14. P2Y receptors are present in almost all human tissues where they exert various biological functions based on their G-protein coupling. P2Y2 is a potential drug target for treating cystic fibrosis. P2Y11 is a regulator of immune response, and a common polymorphism carried by almost 20% of North European caucasians give increased risk of myocardial infarction, making P2Y11 an interesting drug target candidate for treatment of myocardial infarction. P2Y12 is the target of the anti-platelet drug clopidogrel and other thienopyridines.

P2Y Receptor 相关产品 (15):

Cat. No. Product Name Effect Purity
  • HY-B0879A
    Suramin sodium salt Inhibitor 99.93%
    Suramin sodium salt是具有多种生物活性的多磺化萘基脲。 Suramin是DNA拓扑异构酶II抑制剂,IC50为5 μM。
  • HY-10064
    Ticagrelor Antagonist 99.99%
    Ticagrelor (AZD6140)是可逆有口服活性的 P2Y12 受体拮抗剂,可用来治疗血小板聚集。
  • HY-17459
    Clopidogrel hydrogen sulfate Inhibitor
    Clopidogrel是一种抗血小板剂,阻止血小板粘在一起,防止它们形成有害的凝块。
  • HY-13104
    MRS 2578 Antagonist
    MRS2578是P2Y6受体拮抗剂,IC50为37 nM,对P2Y1,P2Y2,P2Y4和P2Y11受体的抑制性较弱。
  • HY-B0606
    Diquafosol tetrasodium Agonist 99.93%
    Diquafosol tetrasodium是一种P2Y2受体激动剂,可刺激眼睛表面的液体和粘蛋白分泌,用于干眼病的局部治疗。
  • HY-15284
    Prasugrel Inhibitor >98.0%
    Prasugrel是ADP受体抑制剂,能通过不可逆的与P2Y12受体结合降低血小板的聚集。
  • HY-18775
    N6-(4-Hydroxybenzyl)adenosine Inhibitor 99.66%
    N6-(4-Hydroxybenzyl)adenosine抑制由胶原诱导的血小板聚集, IC50范围为6.77-141 μM。
  • HY-13831
    BPTU Antagonist 98.03%
    BPTU 是一种新型的 P2Y1 变构拮抗剂。
  • HY-15799
    AZD1283 Antagonist 99.11%
    AZD1283是P2Y12受体拮抗剂,EC50为3.0 ug/kg/min,结合的IC50为11 nM。
  • HY-15876
    Clopidogrel thiolactone Inhibitor >98.0%
    Clopidogrel thiolactone是一种P2Y12受体抑制剂, 是一种有效的抗血小板药物。
  • HY-B0879
    Suramin Inhibitor
    Suramin是具有各种生物活性的多磺化萘脲。Suramin是DNA topoisomerase II抑制剂,IC50值为5 μM。
  • HY-15283
    Clopidogrel Inhibitor
    Clopidogrel 是一种以 P2Y12 受体为靶点的、具有口服活性 的血小板抑制剂。Clopidogrel 可用于抑制冠状动脉疾病、周围血管疾病和脑血管疾病中的血凝块。
  • HY-15284B
    Prasugrel Maleic acid Inhibitor
    Prasugrel马来酸盐是是血小板抑制剂,IC50为1.8 μM。
  • HY-15284A
    Prasugrel hydrochloride Inhibitor
    Prasugrel盐酸盐是血小板抑制剂,IC50为1.8 μM。
  • HY-100254
    TAK-024 Inhibitor
    TAK-024 是一种血小板抑制剂,在人,猴和豚鼠中的 IC50 值分别为 31, 79 和 51 nM。
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