1. MAPK/ERK Pathway
  2. Ribosomal S6 Kinase (RSK)

Ribosomal S6 Kinase (RSK)

Ribosomal S6 Kinase (RSK) is a family of protein kinases involved in signal transduction. There are two subfamilies of rsk, p90rsk, also known as MAPK-activated protein kinase-1 (MAPKAP-K1), and p70rsk, also known as S6-H1 Kinase or simply S6 Kinase. There are three variants of p90rsk in humans, rsk 1-3. Rsks are serine/threonine kinases and are activated by the MAPK/ERK pathway. There are two known mammalian homologues of S6 Kinase: S6K1 and S6K2. Rsk is named for ribosomal protein s6, part of the translational machinery, but several other substrates have been identified, including other ribosomal proteins. Cytosolic substrates of p90rsk include protein phosphatase 1; glycogen synthase kinase 3 (GSK3); L1 CAM, a neural cell adhesion molecule, the Ras exchange factor; and Myt1, an inhibitor of cdc2. p90rsk also regulates transcription factors including cAMP response element-binding protein (CREB); estrogen receptor-α (ERα); IκBα/NF-κB; and c-Fos.

Ribosomal S6 Kinase (RSK) 相关产品 (18):

Cat. No. Product Name Effect Purity
  • HY-10510
    BI-D1870 Inhibitor 99.21%
    BI-D1870 是一种特异性强,ATP 竞争性 RSK 抑制剂,抑制 RSK1、RSK2、RSK3、RSK4 的活性,IC50 值分别为 31 nM、24 nM、18 nM、15 nM。
  • HY-52101
    CMK Inhibitor 98.94%
    CMK 是 RSK2 的抑制剂,常用于抗肿瘤研究。
  • HY-15773
    PF-4708671 Inhibitor 99.96%
    PF-4708671是可渗透入细胞的p70核糖体S6激酶1(S6K1)抑制剂,Ki和IC50分别为20 nM和160 nM。
  • HY-12059
    AT7867 Inhibitor 98.68%
    AT7867 是一种 ATP 竞争性的 Akt1/Akt2/Akt3p70S6K/PKA 抑制剂,IC50 分别为 32 nM/17 nM/47 nM 和 85 nM/20 nM。
  • HY-52101A
    FMK Inhibitor >98.0%
    FMK 是一种不可逆的 RSK2 抑制剂,能够共价修饰 RSK 的 C 末端区域。
  • HY-N0643
    Carnosol Inhibitor
    Carnosol 是一种有效的核糖体S6激酶 (RSK2) 抑制剂,可用于治疗胃癌,其 IC50 值约为 5.5 μM。
  • HY-52101C
    FMK-MEA Inhibitor
    FMK-MEA是一种有效和选择性的p90核糖体S6激酶 (p90 Ribosomal S6 Kinase (RSK)) 抑制剂。
  • HY-16104
    BIX 02565 Inhibitor 98.48%
    BIX 02565 是一种有效的核糖体 S6 激酶 2 (RSK2) 抑制剂,IC50 为 1.1 nM。
  • HY-19713
    LJI308 Inhibitor 99.82%
    LJI308是新型有效的RSK抑制剂, 抑制RSK1, RSK2, 和RSK3 IC50值分别为6 nM, 4 nM, 和13 nM。
  • HY-10579
    Pluripotin Inhibitor 98.03%
    Pluripotin (SC-1) 抑制RSK2 活性, EC50 值为2.5±1.8 μM。
  • HY-N0418
    Quercitrin Inhibitor 98.27%
    槲皮苷 (Quercitrin) 是苦荞麦中的一种天然化合物,具有抗炎作用,常用于治疗心血管疾病。
  • HY-12493A
    LY-2584702 tosylate salt Inhibitor 98.82%
  • HY-19712
    LJH685 Inhibitor 99.90%
    LJH685 是一种有效的选择性RSK抑制剂, 抑制RSK1/2/3 生物活性, IC50为4到13 nM。
  • HY-101963
    AD80 Inhibitor 99.46%
    AD80 是多种激酶的抑制剂,抑制RET, RAF,SRCS6K的活性,但对mTOR的活性明显减弱。
  • HY-12493
    LY-2584702 free base Inhibitor 99.56%
  • HY-16071
    AT13148 Inhibitor 99.46%
    AT13148 是一种可口服的,ATP 竞争性的 AGC kinase 的抑制剂,能够抑制 Akt1/Akt2/Akt3,p70S6K,PKA 和 ROCKI/ROCKII 的活性,IC50 值分别为 38 nM/402 nM/50 nM,8 nM,3 nM 和 6 nM/4 nM。
  • HY-12059A
    AT7867 dihydrochloride Inhibitor 99.77%
    AT7867 dihydrochloride 是一种 ATP 竞争性的 Akt1/Akt2/Akt3p70S6K/PKA 抑制剂,IC50 分别为 32 nM/17 nM/47 nM 和 85 nM/20 nM。
  • HY-12493B
    LY-2584702 hydrochloride Inhibitor
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