1. Immunology/Inflammation
  2. SPHK

SPHK

SphK (sphingosine kinase) is the major source of the bioactive lipid and GPCR (G-protein-coupled receptor) agonist S1P (sphingosine 1-phosphate). S1P promotes cell growth, survival and migration, and is a key regulator of lymphocyte trafficking. Inhibition of S1P signalling has been proposed as a strategy for treatment of inflammatory diseases and cancer.

S1P is an extracellular ligand at five cognate GPCRs, S1PRs and a consequential intracellular lipid intermediate that affects diverse cellular processes including migration, growth and survival. S1P regulates function and trafficking of immune cells, induces angiogenesis and regulates endothelial cell functions, promotes survival and migration of cancer cells, and has been implicated as an important mediator in the pathogenesis of cancer and autoimmune and allergic diseases.

SPHK 相关产品 (11):

Cat. No. Product Name Effect Purity
  • HY-12005
    Fingolimod hydrochloride Antagonist 99.57%
    Fingolimod hydrochloride 是一种 sphingosine 1-phosphate (S1P) 拮抗剂,作用于K562和NK细胞,IC50 为 0.033 nM。
  • HY-16015
    ABC294640 Inhibitor 99.68%
    ABC294640 是一种选择性的竞争性的鞘氨醇激酶 2 (SK2) 抑制剂,Ki 为 9.8 μM。
  • HY-15779A
    K145 hydrochloride Inhibitor 98.00%
    K145盐酸盐是SphK2选择性抑制剂,IC50为4.3μM,在10 μM浓度时对SphK1无抑制性。
  • HY-15425A
    PF-543 Citrate Inhibitor 99.21%
    PF-543 Citrate是新颖的可渗透细胞的SPHK1抑制剂,Ki值为4.3 nM。对SPHK1的选择性是SPHK2的100倍以上。
  • HY-13822
    SKI II Inhibitor 98.69%
    SKI II是一种合成的鞘氨醇激酶 (SK) 抑制剂, 抑制SK1和SK2, IC50值分别为78 μM和45 μM。
  • HY-101805
    SK1-IN-1 Inhibitor >98.0%
    SK1-IN-1是一种有效的鞘氨醇激酶1 (SPHK1) 抑制剂,IC50 值为58 nM。
  • HY-11063
    Fingolimod Antagonist
    Fingolimod 是一种1-磷酸鞘氨醇 (sphingosine 1-phosphateS1P) 拮抗剂,作用于K562 和 NK 细胞,IC50 为 0.033 nM。
  • HY-15779
    K145 Inhibitor
    K145是SphK2选择性抑制剂,IC50为4.3μM,在10 μM浓度时对SphK1无抑制性。
  • HY-19794
    MP-A08 Inhibitor
    MP-A08是一个高的选择性的ATP竞争性的SK抑制剂。
  • HY-15425
    PF-543 Inhibitor
    PF-543是新颖的可渗透细胞的SPHK1抑制剂,Ki值为4.3 nM。对SPHK1的选择性是SPHK2的100倍以上。
  • HY-101572
    MHP Activator
    MHP 是 SPHK1 的激活剂,能够刺激 KC细胞中 CAMP mRNA 的表达和蛋白的产生。