1. Neuronal Signaling
  2. Serotonin Transporter

Serotonin Transporter

Serotonin Transporters (SERTs) are integral membrane proteins that transport serotonin from synaptic spaces into presynaptic neurons. SERTs function by reuptaking serotonin in the synaptic cleft, effectively terminating the function of serotonin and halting neuronal transmission. Serotonin reuptake is a critical process to prevent overstimulation of nerves.

Serotonin transporter (SERT) regulates extracellular levels of serotonin (5-hydroxytryptamine, 5HT) in the brain by transporting 5HT into neurons and glial cells. The human SERT (hSERT) is the primary target for drugs used in the treatment of emotional disorders, including depression. hSERT belongs to the solute carrier 6 family that includes a bacterial leucine transporter (LeuT), for which a high resolution crystal structure has become available.

Serotonin Transporter 相关产品 (35):

Cat. No. Product Name Effect Purity
  • HY-B0102A
    Fluoxetine hydrochloride Inhibitor 99.86%
    Fluoxetine hydrochloride 是一种选择性的羟色胺再摄取抑制剂 (serotonin reuptake inhibitor),常用于抗抑郁研究。
  • HY-B0492
    Paroxetine hydrochloride Inhibitor >99.0%
    Paroxetine hydrochloride 是一种抗抑郁药,为高效的五羟色胺再摄取抑制剂,能抑制 GRK2 活性,IC50 值为 14 μM。
  • HY-B0161A
    Duloxetine hydrochloride Inhibitor 99.92%
    Duloxetine盐酸盐是5-羟色胺-去甲肾上腺素重吸收抑制剂(SNRI),Ki为 4.6 nM。
  • HY-B0176A
    Sertraline hydrochloride Inhibitor 99.84%
    Sertraline盐酸盐是选择性5羟色胺再吸收抑制剂(SSRI)。
  • HY-B1287
    Citalopram hydrobromide Inhibitor >99.0%
    Citalopram盐酸盐是选择性的血清素再摄取抑制剂 (SSRI) 类的抗抑郁药, 已被FDA批准用于治疗抑郁症。
  • HY-14258A
    Escitalopram oxalate Inhibitor >98.0%
    Escitalopram是选择性5羟色胺重吸收抑制剂(SSRI),Ki为0.89 nM。
  • HY-B0103A
    Fluvoxamine maleate Inhibitor 99.85%
    Fluvoxamine马来酸盐是5-羟色胺再吸收抑制剂,有抗抑郁活性。
  • HY-B1490
    Imipramine hydrochloride Inhibitor 99.89%
    Imipramine hydrochloride抑制血清素转运蛋白(serotonin),体内试验的IC50值为32 nM.
  • HY-B0602A
    Desvenlafaxine succinate hydrate Inhibitor 98.25%
    Desvenlafaxine琥珀酸水合物5-羟色胺去甲肾上腺素再摄取抑制剂(SNRI类抗抑郁化合物)。
  • HY-14469
    Sibutramine hydrochloride Inhibitor >98.0%
    Sibutramine hydrochloride 是一种新型的 5-HT (serotonin) 和去甲肾上腺素再摄取抑制剂 (SNRI)。Sibutramine 抑制电压门控 K+ 通道 KV4.3IC50 为 17.3 μM。
  • HY-14261
    Vilazodone Hydrochloride Inhibitor 99.94%
    Vilazodone(EMD 68843; SB 659746A)盐酸盐是五羟色胺重吸收抑制剂(SSRI)和5-HT1A受体部分激动剂。
  • HY-B0168B
    Milnacipran (1S-cis) hydrochloride Inhibitor 99.96%
    Milnacipran (1S-cis) 盐酸盐是一种5-羟色胺去甲肾上腺素再摄取抑制剂 (SNRI), 用于治疗纤维肌痛。
  • HY-B0196A
    Venlafaxine hydrochloride Inhibitor 99.75%
    Venlafaxine盐酸盐是5-羟色胺和去甲肾上腺素重吸收抑制剂(SNRI)。
  • HY-42110
    Dopamine serotonin antagonist-1 Antagonist 99.00%
    Dopamine serotonin antagonist-1是 dopamineserotonin 受体拮抗剂,对多巴胺D1,D2,D4和血清素S2A,S2C,S3的 Ki 值分别为200,2500,420,39,84,40 nM。
  • HY-B0725
    Doxepin Hydrochloride Inhibitor 99.41%
    Doxepin盐酸盐能抑制5-羟色胺和去甲肾上腺素的重吸收,有抗抑郁活性。
  • HY-12850A
    Dasotraline hydrochloride Inhibitor 99.60%
    Dasotraline hydrochloride (SEP-225289 hydrochloride) 是具有阻断多巴胺,去甲肾上腺素和三羟色胺转运蛋白的三重再摄取抑制剂,IC50值分别为4,6和11 nM。
  • HY-B0168A
    Milnacipran hydrochloride Inhibitor 99.40%
    Milnacipran是5-羟色胺-去甲肾上腺素重吸收抑制剂(SNRI),可用于纤维肌痛。
  • HY-B0304A
    Dapoxetine hydrochloride Inhibitor 99.85%
    Dapoxetine盐酸盐短效的选择性5羟色胺重吸收抑制剂。
  • HY-14262
    Vilazodone Inhibitor 99.91%
    Vilazodone(EMD 68843; SB 659746A)是五羟色胺重吸收抑制剂(SSRI)和5-HT1A受体部分激动剂。
  • HY-14261S
    Vilazodone D8 Inhibitor
    Vilazodone D8(Viibryd D8)是vilazodone的氘代化合物标准品。
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