1. Neuronal Signaling
  2. Serotonin Transporter

Serotonin Transporter

Serotonin Transporters (SERTs) are integral membrane proteins that transport serotonin from synaptic spaces into presynaptic neurons. SERTs function by reuptaking serotonin in the synaptic cleft, effectively terminating the function of serotonin and halting neuronal transmission. Serotonin reuptake is a critical process to prevent overstimulation of nerves.

Serotonin transporter (SERT) regulates extracellular levels of serotonin (5-hydroxytryptamine, 5HT) in the brain by transporting 5HT into neurons and glial cells. The human SERT (hSERT) is the primary target for drugs used in the treatment of emotional disorders, including depression. hSERT belongs to the solute carrier 6 family that includes a bacterial leucine transporter (LeuT), for which a high resolution crystal structure has become available.

Serotonin Transporter 相关产品 (41):

Cat. No. Product Name Effect Purity
  • HY-B0102A
    Fluoxetine hydrochloride Inhibitor 99.86%
    Fluoxetine hydrochloride是抗抑郁药和选择性的血清素重吸收抑制剂。
  • HY-B0492
    Paroxetine hydrochloride Inhibitor >99.0%
    Paroxetine hydrochloride 是一种抗抑郁药,为高效的五羟色胺再摄取抑制剂,能抑制 GRK2 活性,IC50 值为 14 μM。
  • HY-B0176A
    Sertraline hydrochloride Inhibitor 99.84%
    Sertraline盐酸盐是选择性5羟色胺再吸收抑制剂(SSRI)。
  • HY-42110
    Dopamine serotonin antagonist-1 Antagonist 99.79%
    Dopamine serotonin antagonist-1是 dopamineserotonin 受体拮抗剂,对多巴胺D1,D2,D4和血清素S2A,S2C,S3的 Ki 值分别为200,2500,420,39,84,40 nM。
  • HY-B1287
    Citalopram hydrobromide Inhibitor >99.0%
    Citalopram盐酸盐是选择性的血清素再摄取抑制剂 (SSRI) 类的抗抑郁药, 已被FDA批准用于治疗抑郁症。
  • HY-N0173
    Cinchonidine Inhibitor >98.0%
    Cinchonidine (α-Quinidine) 是在金鸡纳和角蒿中发现的金鸡纳生物碱。 Cinchonidine (α-Quinidine) 是用于有机化学中不对称合成的砌块。是血清素转运蛋白 (SERT)的弱抑制剂,对于dSERT,hSERT,hSERT I172M,hSERT S438T,hSERT Y95F的 Ki 分别为330,4.2,36,196,15 μM。有抗疟活性[1].。
  • HY-12850
    Dasotraline Inhibitor
    Dasotraline 是一种三重再摄取抑制剂,阻断多巴胺 (dopamine),去甲肾上腺素 (norepinephrine) 和 5-羟色胺 (5-HT) 转运蛋白,IC50 值分别为 4, 6 和 11 nM。
  • HY-16736A
    Centanafadine hydrochloride Inhibitor
    Centanafadine (hydrochloride) 是去甲肾上腺素 (NE)/多巴胺 (DA) 转运的双抑制剂,还能抑制5-羟色胺 (serotonin) 转运体,其对人 NE,DA 和5-羟色胺转运体的IC50 值分别为6 nM,38 nM 和 83 nM。
  • HY-B0103A
    Fluvoxamine maleate Inhibitor 99.85%
    Fluvoxamine马来酸盐是5-羟色胺再吸收抑制剂,有抗抑郁活性。
  • HY-B0161A
    Duloxetine hydrochloride Inhibitor 99.92%
    Duloxetine盐酸盐是5-羟色胺-去甲肾上腺素重吸收抑制剂(SNRI),Ki为 4.6 nM。
  • HY-B1490
    Imipramine hydrochloride Inhibitor 99.89%
    Imipramine hydrochloride抑制血清素转运蛋白(serotonin),体内试验的IC50值为32 nM.
  • HY-14258A
    Escitalopram oxalate Inhibitor >98.0%
    Escitalopram是选择性5羟色胺重吸收抑制剂(SSRI),Ki为0.89 nM。
  • HY-B0457
    Clomipramine hydrochloride Inhibitor 99.72%
    Clomipramine盐酸盐是5-羟色胺转运体(SERT)、去甲肾上腺素转运体(NET)和多巴胺转运体(DAT)阻断剂,Ki分别为0.14,54和3 nM。
  • HY-B0196A
    Venlafaxine hydrochloride Inhibitor 99.75%
    Venlafaxine盐酸盐是5-羟色胺和去甲肾上腺素重吸收抑制剂(SNRI)。
  • HY-B0725
    Doxepin Hydrochloride Inhibitor 99.41%
    Doxepin盐酸盐能抑制5-羟色胺和去甲肾上腺素的重吸收,有抗抑郁活性。
  • HY-B0602A
    Desvenlafaxine succinate hydrate Inhibitor 98.25%
    Desvenlafaxine琥珀酸水合物5-羟色胺去甲肾上腺素再摄取抑制剂(SNRI类抗抑郁化合物)。
  • HY-15414
    Vortioxetine Inhibitor 98.81%
    Vortioxetine 是 5-HT1A,5-HT1B,5-HT3A,5-HT7 受体 和 5-羟色胺转运体 (SERT) 的抑制剂,其 Ki 值分别为 15 nM,33 nM,3.7 nM,19 nM 和 1.6 nM。
  • HY-15414A
    Vortioxetine hydrobromide Inhibitor 99.54%
    Vortioxetine hydrobromide 是5-HT1A,5-HT1B,5-HT3A,5-HT7 受体 和5-羟色胺转运体 (SERT) 的抑制剂,其Ki值分别为 15 nM,33 nM,3.7 nM,19 nM 和 1.6 nM。
  • HY-12850A
    Dasotraline hydrochloride Inhibitor 99.60%
    Dasotraline hydrochloride (SEP-225289 hydrochloride) 是具有阻断多巴胺,去甲肾上腺素和三羟色胺转运蛋白的三重再摄取抑制剂,IC50值分别为4,6和11 nM。
  • HY-14261
    Vilazodone Hydrochloride Inhibitor 99.94%
    Vilazodone Hydrochloride 是 5-羟色胺转运体 (SER) 的抑制剂和 5-HT1A 受体的部分激动剂。
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