1. Signaling Pathways
  2. Cell Cycle/DNA Damage
  3. Telomerase

Telomerase

Telomerase is a ribonucleoprotein that is an enzyme that adds DNA sequence repeats ("TTAGGG" in all vertebrates) to the 3' end of DNA strands in the telomere regions, which are found at the ends of eukaryotic chromosomes. This region of repeated nucleotide called telomeres contains noncoding DNA and hinders the loss of important DNA from chromosome ends. As a result, every time the chromosome is copied, only 100–200 nucleotides are lost, which causes no damage to the organism's DNA. Telomerase is a reverse transcriptase that carries its own RNA molecule, which is used as a template when it elongates telomeres, which are shortened after each replication cycle. Telomerase, a eukaryotic ribonucleoprotein (RNP) complex, contains both an essential RNA and a protein reverse transcriptase subunit. By reverse transcription, the telomerase RNP maintains telomere length stability in almost all cancer cells.

Telomerase 相关产品 (5):

Cat. No. Product Name Effect Purity
  • HY-15595A
    360A iodide Inhibitor >98.0%
    360A iodide 是一种 G-四联体 (G-quadruplex) 的稳定剂,同时可抑制端粒酶 (telomerase) 的活性,在 TRAP-G4 实验中,IC50 值为 300 nM。
  • HY-17353
    BIBR 1532 Inhibitor 99.55%
    BIBR 1532 是一种有效的,选择性的 telomerase 非竞争性抑制剂,IC50 值为 100 nM。
  • HY-15595
    360A Inhibitor
    360A 是一种 G-四联体 (G-quadruplex) 的稳定剂,同时可抑制端粒酶 (telomerase) 的活性,在 TRAP-G4 实验中,IC50 值为 300 nM。
  • HY-108477
    TMPyP4 tosylate Inhibitor
    TMPyP4 tosylate (TMP 1363) 是一种四链体 (G-quadruplex) 特异性配体,可抑制 G-四链体和 IGF-1 之间的相互作用。TMPyP4 tosylate (TMP 1363) 是一种端粒酶 (telomerase) 抑制剂,在骨肉瘤细胞系中具有抗肿瘤作用。
  • HY-U00268
    Telomerase-IN-1 Inhibitor
    Telomerase-IN-1 是一个端粒酶抑制剂,IC50 值为 0.19 μM.
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