1. Cell Cycle/DNA Damage
  2. Topoisomerase

Topoisomerase

Topoisomerases are enzymes that regulate the overwinding or underwinding of DNA. The winding problem of DNA arises due to the intertwined nature of its double-helical structure. Topoisomerases are isomerase enzymes that act on the topology of DNA. Type I topoisomerase cuts one strand of a DNA double helix, relaxation occurs, and then the cut strand is reannealed. Type I topoisomerases are subdivided into two subclasses: type IA topoisomerases, which share many structural and mechanistic features with the type II topoisomerases, and type IB topoisomerases, which utilize a controlled rotary mechanism. Type II topoisomerase cuts both strands of one DNA double helix, pass another unbroken DNA helix through it, and then reanneal the cut strands. This class is also split into two subclasses: type IIA and type IIB topoisomerases, which possess similar structure and mechanisms.

Topoisomerase Isoform Specific Products:

  • Topoisomerase

  • Topo I

  • Topo II

Topoisomerase 相关产品 (60):

Cat. No. Product Name Effect Purity
  • HY-15142
    Doxorubicin hydrochloride Inhibitor 99.47%
    Doxorubicin hydrochloride是一种有细胞毒性的蒽环类抗生素,用于治疗多种癌症。 Doxorubicin 在癌细胞中起作用的可能机制是嵌入 DNA 和破坏 topoisomerase-II 介导的DNA修复。
  • HY-13629
    Etoposide Inhibitor 99.65%
    Etoposide是用于治疗多种癌症的化疗药物。 Etoposide通过与拓扑异构酶II和DNA形成复合物来抑制DNA合成
  • HY-16560
    Campathecin Inhibitor 98.26%
    Campathecin 是有效的 DNA拓扑异构酶 I 抑制剂,IC50 值为 679 nM。
  • HY-16562
    Irinotecan Inhibitor 99.84%
    Irinotecan是水溶性的拓扑异构酶I抑制剂,通过与拓扑异构酶I-DNA复合物结合来防止DNA链的再连接。
  • HY-16261
    Aldoxorubicin Inhibitor
    Aldoxorubicin (INNO-206) 是多柔比星的白蛋白结合前药,在酸性条件下从白蛋白中释放出来。 Aldoxorubicin (INNO-206) 在各种癌细胞系和小鼠肿瘤模型中具有有效的抗肿瘤活性。
  • HY-U00248A
    LMP744 hydrochloride Inhibitor
    LMP744 hydrochloride (MJ-III65 hydrochloride) 是一种 DNA 嵌和剂,是 拓扑异构酶 1 (Top1) 抑制剂,具有抗肿瘤活性。
  • HY-N2306A
    Aclacinomycin A hydrochloride Inhibitor 98.08%
    Aclacinomycin A hydrochloride (Aclarubicin hydrochloride) 是一种荧光分子,是第一个发现对 20S 蛋白酶体 (20S proteasome) 的CTRL (糜凝乳蛋白酶样) 活性具有离散特异性的非肽性抑制剂。同时也是 拓扑异构酶 I 和 II (topoisomerase I and II) 的双抑制剂。是一种有效治疗血癌和实体肿瘤的蒽环类化疗药物。
  • HY-16261B
    MC-DOXHZN hydrochloride Inhibitor
    MC-DOXHZN hydrochloride 是 Doxorubicin 的白蛋白结合前药,具有酸敏感性。
  • HY-13624A
    Epirubicin hydrochloride Inhibitor 98.15%
    Epirubicin hydrochloride 是阿霉素的半合成的 L-阿拉伯糖衍生物,能够抑制 Topoisomerase,起到抗肿瘤的作用。
  • HY-13704
    SN-38 Inhibitor 99.46%
    SN-38 (NK012) 是拓扑异构酶I抑制剂伊立替康的活性代谢产物。 SN-38 (NK012) 抑制DNA合成RNA 合成IC50分别为0.077 和 1.3 μM。
  • HY-13768A
    Topotecan Hydrochloride Inhibitor 99.20%
    Topotecan Hydrochloride (SKF 104864A; NSC 609669) 是具有抗癌活性的 拓扑异构酶I 抑制剂。
  • HY-13062
    Daunorubicin Hydrochloride Inhibitor 99.27%
    Daunorubicin hydrochloride是具有有效抗肿瘤活性的DNA拓扑异构酶II抑制剂。
  • HY-16562A
    Irinotecan hydrochloride Inhibitor 99.75%
    Irinotecan hydrochloride是一种水溶性的拓扑异构酶I抑制剂,主要用于治疗结肠癌和直肠癌。
  • HY-13502
    Mitoxantrone Inhibitor >98.0%
    Mitoxantrone是拓扑异构酶II (topoisomerase II)的抑制剂;也可抑制蛋白激酶C (PKC), IC50值为8.5 μM。
  • HY-13631A
    Exatecan Mesylate Inhibitor 99.12%
    Exatecan Mesylate 是一种水溶性的拓扑异构酶 I (topoisomerase I) 抑制剂,IC50 值为 2.2 μM (0.975 μg/mL),可用于癌症研究。
  • HY-13061
    Daun02 Inhibitor 98.56%
    Daun02是拓扑异构酶抑制剂Daunorubicin的前药。
  • HY-17381
    Idarubicin hydrochloride Inhibitor 99.62%
    Idarubicin hydrochloride是一种蒽环类抗白血病药物。 它抑制 拓扑异构酶II,干扰DNA复制和RNA转录。
  • HY-13555
    β-Lapachone Inhibitor 99.72%
    β-Lapachone 是一种天然的萘醌类化合物,是拓扑异构酶 I (topoisomerase I) 抑制剂,通过抑制细胞周期进程来诱导细胞凋亡。
  • HY-16568
    Irinotecan hydrochloride trihydrate Inhibitor 99.59%
    Irinotecan hydrochloride trihydrate 是一种水溶性的拓扑异构酶 I (topoisomerase I) 抑制剂,具有抗肿瘤活性。
  • HY-10529
    Betulinic acid Inhibitor 98.58%
    Betulinic acid 是一种天然的五环三萜类化合物,为真核细胞拓扑异构酶 I (topoisomerase I) 的抑制剂,IC50 值为 5 μM,具有抗炎,抗疟疾,抗艾滋病和抗肿瘤等活性。
Isoform Specific Products

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