1. Stem Cell/Wnt
  2. Wnt


The Wnt signaling pathways are a group of signal transduction pathways made of proteins that pass signals from outside of a cell through cell surface receptors to the inside of the cell. Three Wnt signaling pathways have been characterized: the canonical Wnt pathway, the noncanonical planar cell polarity pathway, and the noncanonical Wnt/calcium pathway. All three Wnt signaling pathways are activated by the binding of a Wnt-protein ligand to a Frizzled family receptor, which passes the biological signal to the protein Dishevelled inside the cell. The canonical Wnt pathway leads to regulation of gene transcription, the noncanonical planar cell polarity pathway regulates the cytoskeleton that is responsible for the shape of the cell, and the noncanonical Wnt/calcium pathway regulates calcium inside the cell. The clinical importance of Wnt signaling pathway has been demonstrated by mutations that lead to a variety of diseases, including breast and prostate cancer, glioblastoma, type II diabetes.

Wnt 相关产品 (31):

Cat. No. Product Name Effect Purity
  • HY-14428
    ICG-001 Inhibitor 99.61%
    ICG-001 是一种 Wnt/β-catenin/TCF -介导的转录拮抗剂,特别结合元件结合蛋白 (CBP),IC50 值为 3 μM。
  • HY-15597
    Salinomycin Inhibitor >98.0%
    Salinomycin 是一种 Wnt/β-catenin 通道抑制剂,作用于 Wnt/Fzd/LRP 复合体。Salinomycin强抑制 Wnt1刺激的报告基因活性,IC50 为 163 nM,且降低 β-catenin 水平。
  • HY-12238
    IWR-1 Inhibitor 99.83%
    IWR-1 是一种 Wnt 抑制剂,在 L Wnt-3A 细胞中,IC50 值为 180 nM,通过稳定 Axin 破坏复合体来提高β-连环素的磷酸化。
  • HY-18988
    ETC-159 Inhibitor 98.67%
    ETC-159是有效的,具有口服活性的PORCN抑制剂。抑制β-catenin报告基因活性的IC50值为2.9 nM。
  • HY-15659
    Wnt-C59 Inhibitor 99.56%
    Wnt-C59 有效抑制 PORCN 酶活性和 Wnt
  • HY-12637
    Hexachlorophene Inhibitor 99.66%
  • HY-101085
    SKL2001 Agonist 98.08%
    SKL2001 是 Wnt/β-catenin 信号通路的激动剂,具有抗肿瘤活性。
  • HY-109049
    Adavivint Inhibitor >98.0%
    Adavivint 是一种有效的,选择性的典型的 Wnt 信号通路抑制剂,在 SW480 细胞中,用高通量 TCF/LEF 报告基因实验,测得 EC50 值为 19.5 nM。
  • HY-17577
    Berberine chloride hydrate Activator 99.56%
    Berberine chloride hydrate能有效的抑制多种癌细胞增殖,促进凋亡,能影响MAPK和Wnt/β-catenin通路。
  • HY-A0293
    Pyrvinium pamoate Inhibitor >98.0%
    Pyrvinium pamoate是一种有效驱虫剂,也是WNT有效抑制剂。
  • HY-13912
    IWP-2 Inhibitor
    IWP-2 抑制 Wnt 加工和分泌,IC50 为 27 nM。
  • HY-19987
    BML-284 Activator 99.92%
    BML-284是有效的选择性, 及细胞渗透性的Wnt信号激活剂。
  • HY-16665
    iCRT 14 Inhibitor 98.90%
    iCRT 14 是一种 β-连环蛋白应答转录(CRT)抑制剂,能够抑制 Wnt 信号通路,IC50 值为 40.3 nM。
  • HY-15721
    FH535 Inhibitor 99.93%
    FH535 是 Wnt/β-cateninPPAR 的抑制剂,具有抗肿瘤活性。
  • HY-101090
    KYA1797K Inhibitor >98.0%
    KYA1797K是有效,选择性的 Wnt/β-catenin 抑制剂,IC50 值为0.75 µM。
  • HY-12681
    CCT251545 Inhibitor 99.34%
    CCT251545是一种口服生物有效的WNT抑制剂, IC50值为5 nM。
  • HY-101916
    Heparan Sulfate
    Heparan sulfate是一种复杂的线性多糖。它作为硫酸乙酰肝素蛋白聚糖的一部分出现,在细胞表面和细胞外基质中表达丰富。
  • HY-100830
    NCB-0846 Inhibitor 98.27%
    NCB-0846是具有口服活性的TNIK抑制剂,IC50值为21 nM。
  • HY-N0400
    Wogonin Inhibitor 99.83%
    Wogonin 是一种天然黄酮类物质,能够抑制 CDK8 and Wnt 的活性,具有抗炎、抗肿瘤等功效。
  • HY-19739
    JW74 Antagonist 99.93%
    JW74 拮抗 LiCl 诱导的经典 Wnt 信号传导的激活,IC50 为 420 nM。
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