1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. nAChR

nAChR

nAChRs (nicotinic acetylcholine receptors) are neuron receptor proteins that signal for muscular contraction upon a chemical stimulus. They are cholinergic receptors that form ligand-gated ion channels in the plasma membranes of certain neurons and on the presynaptic and postsynaptic sides of theneuromuscular junction. Nicotinic acetylcholine receptors are the best-studied of the ionotropic receptors. Like the other type of acetylcholine receptor-the muscarinic acetylcholine receptor (mAChR)-the nAChR is triggered by the binding of the neurotransmitter acetylcholine (ACh). Just as muscarinic receptors are named such because they are also activated by muscarine, nicotinic receptors can be opened not only by acetylcholine but also by nicotine —hence the name "nicotinic".

nAChR 相关产品 (36):

Cat. No. Product Name Effect Purity
  • HY-12560A
    PNU-282987 Agonist 99.37%
    PNU-282987是_alpha_7 nAChR受体选择性激动剂,Ki值为26nM,对_alpha_1_beta_1_gamma__delta_和_alpha_3_beta_4nAChRs亲和力弱。
  • HY-17418
    Vinblastine Inhibitor >98.0%
    Vinblastine是一种针对各种癌症类型的有细胞毒性的生物碱。 长春花碱可抑制微管的形成,抑制nAChR的IC50值为8.9 μM。
  • HY-14564A
    GTS-21 dihydrochloride Agonist 99.76%
    GTS-21二盐酸盐是一种选择性α7烟碱型乙酰胆碱受体 (α7nAChR) 激动剂。
  • HY-12152
    PNU-120596 Agonist 99.22%
    PNU-120596 (NSC 216666)是α7 nAChR正向变构调节剂,EC50为0.2 μM。
  • HY-14774
    Monepantel Agonist 99.43%
    Monepantel 是一种有机驱虫剂,也是 nAChR 的正调节剂。
  • HY-N2332A
    Methyllycaconitine citrate Antagonist >98.0%
    Methyllycaconitine citrate 是 α7 神经元烟碱型乙酰胆碱受体 (α7nAChR) 的特异性拮抗剂。
  • HY-107675
    Desformylflustrabromine hydrochloride Agonist 99.77%
    Desformylflustrabromine hydrochloride 是一个有选择性的 α4β2 神经元烟碱乙酰胆碱受体 (nAChR) 激动剂,其 pEC50 值为 6.48。
  • HY-12151
    NS 1738 Agonist 99.21%
    NS 1738 是一种新型的 α7 nAChR 正向变构调节剂。在卵母细胞实验中,正调节 α7nAChR,EC50 为 3.4 μM。
  • HY-15430A
    EVP-6124 hydrochloride Agonist 98.20%
    EVP-6124 hydrochloride 是一种新型 α7 神经元烟碱乙酰胆碱受体 (nAChRs)激动剂。
  • HY-10019
    Varenicline Agonist 99.98%
    Varenicline(CP 526555;Champix) is a selective α4β2 nicotinic receptor partial agonist; it stimulates nicotine receptors more weakly than nicotine itself does.
  • HY-B0429
    Pancuronium dibromide Antagonist >98.0%
    Pancuronium Dibromide是竞争性AChR拮抗剂,IC50为5.5 nM。
  • HY-14316A
    Tebanicline hydrochloride Modulator 98.00%
    Tebanicline hydrochloride (ABT594 hydrochloride) 是nAChR的调节物,具有有效的口服止痛活性。抑制cytisine与神经元nAChR的结合的Ki值为37 pM。
  • HY-11013
    ZSET1446 Agonist 98.03%
    ZSET1446 是一种新颖的促进认知药,在不同的阿尔茨海默病模型中,能够改善学习功能障碍。
  • HY-B0569
    Hexamethonium Bromide Antagonist >98.0%
    溴化Hexamethonium是非去极化的神经节阻断剂,是nAChR拮抗剂。
  • HY-10932
    Aniracetam Modulator 99.43%
    Aniracetam(Ro 13-5057)可调节AMPA受体和nAChR,具有神经保护和益智作用。
  • HY-N0252
    Catharanthine Inhibitor 98.66%
    Catharanthine是一种由长春花提取的生物碱,能抑制烟碱受体介导的隔膜收缩,IC50为59.6μM
  • HY-17555
    Meclofenoxate hydrochloride Inhibitor
    Meclofenoxate盐酸盐是DMAE和pCPA合成的酯,有刺激记忆和提高认知的活性。
  • HY-B0979
    Lobeline hydrochloride Agonist 99.64%
    Lobeline盐酸盐是烟碱样受体激动剂, 作为有效的神经元烟碱受体α3β2和α4β2拮抗剂。
  • HY-B0827
    Dinotefuran Inhibitor 99.92%
    Dinotefuran是一种新型烟碱类杀虫剂, 作用机理是通过抑制烟碱乙酰胆碱受体而破坏昆虫的神经系统。
  • HY-B0379A
    Adiphenine hydrochloride Inhibitor 99.62%
    Adiphenine盐酸盐是烟碱受体抑制剂,具解痉挛活性。
Isoform Specific Products

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.