1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. nAChR

nAChR

nAChRs (nicotinic acetylcholine receptors) are neuron receptor proteins that signal for muscular contraction upon a chemical stimulus. They are cholinergic receptors that form ligand-gated ion channels in the plasma membranes of certain neurons and on the presynaptic and postsynaptic sides of theneuromuscular junction. Nicotinic acetylcholine receptors are the best-studied of the ionotropic receptors. Like the other type of acetylcholine receptor-the muscarinic acetylcholine receptor (mAChR)-the nAChR is triggered by the binding of the neurotransmitter acetylcholine (ACh). Just as muscarinic receptors are named such because they are also activated by muscarine, nicotinic receptors can be opened not only by acetylcholine but also by nicotine —hence the name "nicotinic".

nAChR 相关产品 (34):

Cat. No. Product Name Effect Purity
  • HY-12560A
    PNU-282987 Agonist 99.37%
    PNU-282987是_alpha_7 nAChR受体选择性激动剂,Ki值为26nM,对_alpha_1_beta_1_gamma__delta_和_alpha_3_beta_4nAChRs亲和力弱。
  • HY-B0638
    L-Nicotine Agonist 99.96%
    L-Nicotine是原型烟酸乙酰胆碱受体激动剂;天然异构体。
  • HY-17418
    Vinblastine Inhibitor >98.0%
    Vinblastine是一种针对各种癌症类型的有细胞毒性的生物碱。 长春花碱可抑制微管的形成,抑制nAChR的IC50值为8.9 μM。
  • HY-B1208
    Carbamoylcholine chloride Agonist >98.0%
    Carbamoylcholine氯化物用来研究nAChR和mAchR的介导的反应, 包括平滑肌收缩, 肠运动, 与神经信号。Carbamoylcholine是乙酰胆碱类似物, 激活乙酰胆碱受体 (AChR), Carbamoylcholine是nAChR和mAchR受体激动剂, 针对不同的受体, Ki值为10到10,000 nM。
  • HY-14564A
    GTS-21 dihydrochloride Agonist 99.66%
    GTS-21二盐酸盐是一种选择性α7烟碱型乙酰胆碱受体 (α7nAChR) 激动剂。
  • HY-106268A
    Larazotide acetate Antagonist
    Larazotide acetate (AT-1001) 是高亲和性和选择性的α3β4烟碱乙酰胆碱受体 (nAChR) 拮抗剂,IC50 值为35.2 nM。
  • HY-U00281
    S16961 Agonist
    S16961 是一种烟碱受体激动剂。
  • HY-10019
    Varenicline Agonist 99.98%
    Varenicline(CP 526555;Champix) is a selective α4β2 nicotinic receptor partial agonist; it stimulates nicotine receptors more weakly than nicotine itself does.
  • HY-12152
    PNU-120596 Agonist 99.22%
    PNU-120596 (NSC 216666)是α7 nAChR正向变构调节剂,EC50为0.2 μM。
  • HY-B0429
    Pancuronium dibromide Antagonist >98.0%
    Pancuronium Dibromide是竞争性AChR拮抗剂,IC50为5.5 nM。
  • HY-B0569
    Hexamethonium Bromide Antagonist 98.12%
    溴化Hexamethonium是非去极化的神经节阻断剂,是nAChR拮抗剂。
  • HY-N0252
    Catharanthine Inhibitor 99.88%
    Catharanthine是一种由长春花提取的生物碱,能抑制烟碱受体介导的隔膜收缩,IC50为59.6μM
  • HY-14774
    Monepantel Agonist 99.43%
    Monepantel 是一种有机驱虫剂,也是 nAChR 的正调节剂。
  • HY-14316A
    Tebanicline hydrochloride Modulator 98.00%
    Tebanicline hydrochloride (ABT594 hydrochloride) 是nAChR的调节物,具有有效的口服止痛活性。抑制cytisine与神经元nAChR的结合的Ki值为37 pM。
  • HY-10932
    Aniracetam Modulator 99.43%
    Aniracetam(Ro 13-5057)可调节AMPA受体和nAChR,具有神经保护和益智作用。
  • HY-11013
    ZSET1446 Agonist 98.03%
    ZSET1446 是一种新颖的促进认知药,在不同的阿尔茨海默病模型中,能够改善学习功能障碍。
  • HY-15430A
    EVP-6124 hydrochloride Agonist 98.20%
    EVP-6124 hydrochloride 是一种新型 α7 神经元烟碱乙酰胆碱受体 (nAChRs)激动剂。
  • HY-B0827
    Dinotefuran Inhibitor 99.92%
    Dinotefuran是一种新型烟碱类杀虫剂, 作用机理是通过抑制烟碱乙酰胆碱受体而破坏昆虫的神经系统。
  • HY-B0379A
    Adiphenine hydrochloride Inhibitor 99.75%
    Adiphenine盐酸盐是烟碱受体抑制剂,具解痉挛活性。
  • HY-B0118A
    Vecuronium bromide Inhibitor >98.0%
    溴化Vecuronium是非去极化阻断剂,可使肌肉松弛。