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UM171 是一种选择性的人造血干细胞自我更新的激动剂。UM171 与造血细胞因子结合,具有促进人原代 HSC 在体外维持和扩增的能力。UM171 可用于体外人多能干细胞造血衍生的研究。

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UM171 Chemical Structure

UM171 Chemical Structure

CAS No. : 1448724-09-1

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规格 价格 是否有货 数量
5 mg ¥1100
In-stock
10 mg ¥1800
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25 mg ¥3400
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50 mg ¥6100
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200 mg   询价  

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Customer Review

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

UM171 is a selective agonist of human hematopoietic stem cell self-renewal. UM171 binds to hematopoietic cytokines and has the ability to promote the maintenance and expansion of human primary HSCs in vitro. UM171 can be used in the study of hematopoietic derivation of human pluripotent stem cells in vitro.

体外研究
(In Vitro)

UM171 (50-100 nM) significantly increases CD34+ CD43+ and CD34+ CD45+ hematopoietic progenitors. UM171 enhances the derivation of hematopoietic cells at multiple developmental steps. UM171 enhances de novo generation of hematopoietic progenitor cells from hPSCs at multiple phases during hematopoietic differentiation in vitro. UM171 shows no effect on erythroid development, but inhibits erythroid maturation[1]. UM171 treatment enhances the engraftment potential of CD34+ macaque cells by threefold. UM171 attenuates cell differentiation and promotes ex vivo expansion of primitive human hematopoietic cells, and promotes expansion of LT-HSCs. UM171 treatment results in down-regulation of AhR target genes such as CYP1B1, CYP1A1, and AhRR[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

453.54

Formula

C25H27N9

CAS 号
性状

固体

颜色

Off-white to yellow

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : ≥ 75 mg/mL (165.37 mM; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.2049 mL 11.0244 mL 22.0488 mL
5 mM 0.4410 mL 2.2049 mL 4.4098 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 98.14%

参考文献

UM171 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2049 mL 11.0244 mL 22.0488 mL 55.1219 mL
5 mM 0.4410 mL 2.2049 mL 4.4098 mL 11.0244 mL
10 mM 0.2205 mL 1.1024 mL 2.2049 mL 5.5122 mL
15 mM 0.1470 mL 0.7350 mL 1.4699 mL 3.6748 mL
20 mM 0.1102 mL 0.5512 mL 1.1024 mL 2.7561 mL
25 mM 0.0882 mL 0.4410 mL 0.8820 mL 2.2049 mL
30 mM 0.0735 mL 0.3675 mL 0.7350 mL 1.8374 mL
40 mM 0.0551 mL 0.2756 mL 0.5512 mL 1.3780 mL
50 mM 0.0441 mL 0.2205 mL 0.4410 mL 1.1024 mL
60 mM 0.0367 mL 0.1837 mL 0.3675 mL 0.9187 mL
80 mM 0.0276 mL 0.1378 mL 0.2756 mL 0.6890 mL
100 mM 0.0220 mL 0.1102 mL 0.2205 mL 0.5512 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Inquiry Information

产品名称:
UM171
目录号:
HY-12878
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