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WIN site inhibitor 1 

目录号: HY-111753
产品使用指南

WIN site inhibitor 1 是一种染色质相关 WD 重复结构域 5 蛋白 (WDR5) 的 WIN 位点抑制剂,Kd 值为 0.1 nM。WIN site inhibitor 1 能够从染色质中取代 WDR5,并降低相关基因的表达,引起翻译抑制和核仁应激。具有抗癌作用。

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WIN site inhibitor 1 Chemical Structure

WIN site inhibitor 1 Chemical Structure

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Description

WIN site inhibitor 1 is an inhibitor of the WIN site of chromatin-associated WD repeat-containing protein 5 (WDR5), with a Kd of 0.1 nM. WIN site inhibitor 1 displaces WDR5 from chromatin and decreases the expression of associated genes, causing translational inhibition, nucleolar stress. Anti-cancer activity[1].

IC50 & Target

Kd: 0.1 nM (WIN)[1]

References
Molecular Weight

498.38

Formula

C₂₅H₂₂Cl₂FN₅O

SMILES

ClC1=CC=C(CNC(C2=CC(CN3C(N(C)C=C3)=N)=CC(C4=C(C)N=C(F)C=C4)=C2)=O)C=C1Cl

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
WIN site inhibitor 1
目录号:
HY-111753
需求量:

WIN site inhibitor 1

Cat. No.: HY-111753