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WS-383 

目录号: HY-126075A
产品使用指南

WS-383 是一种有效、选择性、可逆的 DCN1-UBC12 相互作用抑制剂,IC50 值为 11 nM。WS-383 抑制 Cul3/1 的类泛素化修饰,引起 p21,p27 和 NRF2 的积累。

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WS-383 Chemical Structure

WS-383 Chemical Structure

CAS No. : 2247544-02-9

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Description

WS-383 is a potent, selective and reversible inhibitor of DCN1-UBC12 interaction, with an IC50 of 11 nM. WS-383 inhibits Cul3/1 neddylation, induces accumulation of p21, p27 and NRF2[1].

IC50 & Target

IC50: 11 nM (DCN1-UBC12 interaction)[1]

References
Molecular Weight

498.46

Formula

C₁₈H₂₁Cl₂N₉S₂

CAS No.

2247544-02-9

SMILES

CN(C)CCN1N=NN=C1SC2=CC(C)=NC3=NC(SCC4=CC=C(Cl)C=C4)=NN23.Cl

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
WS-383
目录号:
HY-126075A
需求量:

WS-383

Cat. No.: HY-126075A