2. Immunology/Inflammation Metabolic Enzyme/Protease Apoptosis Anti-infection
  3. COX Acyltransferase Apoptosis HSV CMV Influenza Virus
  4. Xanthohumol

Xanthohumol  (Synonyms: 黄腐酚)

目录号: HY-N1067 纯度: 99.97%
COA 产品使用指南

摩尔计算器

Xanthohumol 是从啤酒花中分离到的黄酮类化合物，是 DGAT，COX-1 和 COX-2 的抑制剂，具有抗肿瘤，抗血管生成的作用。Xanthohumol 还具有抗牛病毒性腹泻病毒 (BVDV)，鼻病毒，HSV-1，HSV-2 和 巨细胞病毒 (CMV) 的抗病毒活性。

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Xanthohumol Chemical Structure

Xanthohumol Chemical Structure

CAS No. : 6754-58-1

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥770
In-stock
5 mg ￥700
In-stock
10 mg ￥1100
In-stock
25 mg ￥2200
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Xanthohumol:

Xanthohumol 相关抗体

Top Publications Citing Use of Products

    Xanthohumol purchased from MCE. Usage Cited in: Phytother Res. 2023 Mar 7.  [Abstract]

    Xanthohumol (XN; 25 mg/kg; i.p.; single daily for 30 days) significantly suppresses the tumor growth and reduces the final tumor weight by 50.4% (Fig a-c).

    Xanthohumol purchased from MCE. Usage Cited in: Phytother Res. 2023 Mar 7.  [Abstract]

    Xanthohumol (XN; 10, 15, 20 μM; 36 h) suppresses the serum-induced migratory ability of A549 cells.

    Xanthohumol purchased from MCE. Usage Cited in: Phytother Res. 2023 Mar 7.  [Abstract]

    Xanthohumol (XN; 10, 15, 20 μM; 36 h) results in a dose-dependent inhibition of TOPK phosphorylation (Thr9), and inhibits the phosphorylation of histone H3 and Akt, in both HCC827 cells (fig c) and HCT116 cells (Fig d).

    查看 COX 亚型特异性产品:

    查看所有亚型
    COX COX-1 COX-2 COX-3

    查看 Acyltransferase 亚型特异性产品:

    查看所有亚型
    ACAT1 ACAT2 MGAT2 ACAT

    • 生物活性

    • 实验参考方法

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Xanthohumol is one of the principal flavonoids isolated from hops, the inhibitor of diacylglycerol acetyltransferase (DGAT), COX-1 and COX-2, and shows anti-cancer and anti-angiogenic activities. Xanthohumol also has antiviral activity against bovine viral diarrhea virus (BVDV), rhinovirus, HSV-1, HSV-2 and cytomegalovirus (CMV).

    IC50 & Target[1][2][3][4][5]

    COX-1

     

    COX-2

     

    HSV-1

     

    HSV-2

     

    DGAT1

    40 μM (IC50)

    DGAT2

    40 μM (IC50)

    CMV

     

    体外研究
    (In Vitro)

    Xanthohumol significantly attenuates ADP-induced blood platelet aggregation, and significantly reduces the expression of fibrinogen receptor (activated form of GPIIbIIIa) on platelets' surface[1].
    Xanthohumol (5-50 nM) reduces the frequency of spontaneously occurring Ca2+ sparks and Ca2+ waves in control myocytes and in cells subjected to Ca2+ overload caused by: (1) exposure to low K+ solutions, (2) periods of high frequency electrical stimulation, (3) exposures to isoproterenol or (4) caffeine. Xanthohumol (50-100 nM) reduces the rate of relaxation of electrically- or caffeine-triggered Ca2+ transients, without suppressing ICa, but this effect is small and reversed by isoproterenol at physiological temperatures. Xanthohumol also suppresses the Ca2+ content of the SR, and its rate of recirculation[2].
    Treatment of endothelial cells with Xanthohumol leads to increased AMPK phosphorylation and activity. Functional studies using biochemical approaches confirm that AMPK mediates Xanthohumol anti-angiogenic activity. AMPK activation by Xanthohumol is mediated by CAMMKβ, but not LKB1. Analysis of the downstream mechanisms shows that Xanthohumol-induced AMPK activation reduces nitric oxide (NO) levels in endothelial cells by decreasing eNOS phosphorylation. Finally, AKT pathway is inactivated by Xanthohumol as part of its anti-angiogenic activity, but independently from AMPK, suggesting that these two signaling pathways proceed autonomously[3].
    Xanthohumol significantly reduces cell viability and induces apoptosis via pro-caspase-3/8 cleavage and poly(ADP ribose) polymerase (PARP) degradation. Pro-caspase-9 cleavage, Bcl2 family expression changes, mitochondrial dysfunction, and intracellular ROS generation also participate in Xanthohumol-induced glioma cell death. Xanthohumol's inhibition of the IGFBP2/AKT/Bcl2 pathway via miR-204-3p targeting plays a critical role in mediating glioma cell death[4].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Xanthohumol 相关抗体:
    Clinical Trial
    分子量

    354.40

    Formula

    C21H22O5
    CAS 号
    性状

    固体

    颜色

    Yellow to orange

    结构分类
    初始来源
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    溶解性数据
    In Vitro: 

    DMSO 中的溶解度 : 83.33 mg/mL (235.13 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 2.8217 mL 14.1084 mL 28.2167 mL
    5 mM 0.5643 mL 2.8217 mL 5.6433 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    In Vivo:

    请根据您的 实验动物和给药方式 选择适当的溶解方案。

    以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
    ——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
    以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

    • 方案 一

      请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.08 mg/mL (5.87 mM); 澄清溶液

      此方案可获得 ≥ 2.08 mg/mL（饱和度未知）的澄清溶液。

      以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；再向上述体系中加入 50 μL Tween-80，混合均匀；然后再继续加入 450 μL 生理盐水 定容至 1 mL。

      生理盐水的配制：将 0.9 g 氯化钠，溶解于 ddH₂O 并定容至 100 mL，可以得到澄清透明的生理盐水溶液。
    • 方案 二

      请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.08 mg/mL (5.87 mM); 澄清溶液

      此方案可获得 ≥ 2.08 mg/mL（饱和度未知）的澄清溶液。

      以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液 中，混合均匀。

      20% SBE-β-CD in Saline 的配制（4°C，储存一周）：2 g SBE-β-CD（磺丁基醚 β-环糊精）粉末定容于 10 mL 的生理盐水中，完全溶解至澄清透明。
    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    请输入您的动物体内配方组成：
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    如果您的动物是免疫缺陷鼠或者体弱鼠，建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。
    方案所需 助溶剂 包括：DMSO， ，均可在 MCE 网站选购。 ，Tween 80，均可在 MCE 网站选购。
    计算结果
    工作液所需浓度 : mg/mL
    储备液配制方法 : mg 药物溶于 μL  DMSO（母液浓度为 mg/mL）。
    您所需的储备液浓度超过该产品的实测溶解度，以下方案仅供参考，如有需要，请与 MCE 中国技术支持联系。
    动物实验体内工作液的配制方法 : 取 μL DMSO 储备液，加入 μL 。 μL ，混合均匀至澄清，再加 μL Tween 80，混合均匀至澄清，再加 μL 生理盐水。
    连续给药周期超过半月以上，请谨慎选择该方案。
    请确保第一步储备液溶解至澄清状态，从左到右依次添加助溶剂。您可采用超声加热 （超声清洗仪，建议频次 20-40 kHz），涡旋吹打等方式辅助溶解。
    纯度 & 产品资料

    纯度: 99.97%

    COA (189 KB) HNMR (271 KB) LCMS (97 KB)

    产品使用指南 (1538 KB)
    参考文献
    Cell Assay
    [3]

    In vitro cell proliferation/viability is measured by the MTT test at different time points. 1000 cells/well are plated into 96-multiwell plates in complete medium. Following adhesion, medium is replaced with fresh medium containing the different treatments or vehicle (DMSO in medium). Xanthohumol and EGCG are used in a concentration range from 2.5 to 40 μM, up to 96 hours. 3 hours before each time point, MTT reagent (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) is added to the wells and plates are incubated at 37°C. At the indicated time points, absorbance at 540 nm is then measured by a FLUOstar spectrophotometer.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    参考文献

    Xanthohumol 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.8217 mL 14.1084 mL 28.2167 mL 70.5418 mL
    5 mM 0.5643 mL 2.8217 mL 5.6433 mL 14.1084 mL
    10 mM 0.2822 mL 1.4108 mL 2.8217 mL 7.0542 mL
    15 mM 0.1881 mL 0.9406 mL 1.8811 mL 4.7028 mL
    20 mM 0.1411 mL 0.7054 mL 1.4108 mL 3.5271 mL
    25 mM 0.1129 mL 0.5643 mL 1.1287 mL 2.8217 mL
    30 mM 0.0941 mL 0.4703 mL 0.9406 mL 2.3514 mL
    40 mM 0.0705 mL 0.3527 mL 0.7054 mL 1.7635 mL
    50 mM 0.0564 mL 0.2822 mL 0.5643 mL 1.4108 mL
    60 mM 0.0470 mL 0.2351 mL 0.4703 mL 1.1757 mL
    80 mM 0.0353 mL 0.1764 mL 0.3527 mL 0.8818 mL
    100 mM 0.0282 mL 0.1411 mL 0.2822 mL 0.7054 mL
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Xanthohumol6754-58-1COXAcyltransferaseApoptosisHSVCMVInfluenza VirusCyclooxygenaseDiacylglycerol acyltransferaseDiglyceride acyltransferaseacyl-CoA:cholesterol acyltransferasemono- acylglycerol acyltransferaseHerpes simplex virusCytomegalovirusInhibitorinhibitorinhibit

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