1. Epigenetics
  2. Histone Acetyltransferase
  3. YF-2 hydrochloride

YF-2 hydrochloride 

目录号: HY-16531A
产品使用指南

YF-2 hydrochloride 是一种高度选择性、可透过血脑屏障的组蛋白乙酰转移酶 (histone acetyltransferase) 激动剂,能够在海马区乙酰化 H3,对 CBP,PCAF 和 GCN5 的 EC50 值分别为 2.75 μM,29.04 μM 和 49.31 μM,对 HDAC 无作用。具有抗肿瘤和抗阿尔滋海默症的活性。

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YF-2 hydrochloride Chemical Structure

YF-2 hydrochloride Chemical Structure

CAS No. : 1312005-62-1

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YF-2 hydrochloride 的其他形式现货产品:

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Description

YF-2 hydrochloride is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC50s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect on HDAC. Anti-cancer and anti-Alzheimer's disease[1].

IC50 & Target[1]

CBP

2.75 μM (EC50)

PCAF

29.04 μM (EC50)

GCN5

49.31 μM (EC50)

In Vitro

YF-2 (0.03, 0.1, 0.25, 0.5, 1, 2.5, 5, 15, 40 and 80 μM, 72 hours) inhibits the preliferation of U251, CCRF-CEM, Hs578T, NCI-ADR-RES cells[1].

In Vivo

YF-2 (20 mg/kg, 2 hours befor electric shock or 5 mg/kg, 30 min before the electric shock, i.p.) rescues the defect in contextual memory in mice, and shows no effect on contextual memory alone at 20 mg/kg in mice[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

467.31

Formula

C₂₀H₂₃Cl₂F₃N₂O₃

CAS No.

1312005-62-1

SMILES

O=C(NC1=CC=C(Cl)C(C(F)(F)F)=C1)C2=C(OCC)C=CC=C2OCCN(C)C.Cl

Shipping

Room temperature in continental US; may vary elsewhere

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产品名称:
YF-2 hydrochloride
目录号:
HY-16531A
需求量:

YF-2 hydrochloride

Cat. No.: HY-16531A