1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. nAChR

(-)-(S)-B-973B 

目录号: HY-114269 纯度: 99.93% ee.: 92.97%
产品使用指南

(-)-(S)-B-973B 为一种有效的 α7 nAChR 正向别构调节剂,具有镇痛作用。

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(-)-(S)-B-973B Chemical Structure

(-)-(S)-B-973B Chemical Structure

CAS No. : 2244989-34-0

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Size Price Stock Quantity
10 mM * 1 mL in DMSO ¥3080 In-stock
5 mg ¥2800 In-stock
10 mg ¥4200 In-stock
50 mg ¥12000 In-stock
100 mg ¥19000 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

(-)-(S)-B-973B is a potent allosteric agonism and positive allosteric modulation (ago-PAM) for α7 nAChR, with antinociceptive activity[1].

IC50 & Target

α7 nAChR[1]

Solvent & Solubility
In Vitro: 

DMSO : 67.5 mg/mL (149.17 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2099 mL 11.0497 mL 22.0994 mL
5 mM 0.4420 mL 2.2099 mL 4.4199 mL
10 mM 0.2210 mL 1.1050 mL 2.2099 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.25 mg/mL (4.97 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.25 mg/mL (4.97 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.25 mg/mL (4.97 mM); Clear solution

References
Molecular Weight

452.50

Formula

C₂₄H₂₆F₂N₆O

CAS No.

2244989-34-0

SMILES

O=C(N[C@H](C1=NC(N2CCN(C3=NC=CC=C3)CC2)=CN=C1)C)CCC4=CC=C(F)C(F)=C4

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Inquiry Information

产品名称:
(-)-(S)-B-973B
目录号:
HY-114269
需求量:

(-)-(S)-B-973B

Cat. No.: HY-114269