1. JAK/STAT Signaling
    Protein Tyrosine Kinase/RTK
  2. EGFR
  3. (E)-AG 99

(E)-AG 99 (Synonyms: (E)-Tyrphostin 46; (E)-Tyrphostin AG 99)

目录号: HY-100962 纯度: 99.41%
产品使用指南

(E)-AG 99 ((E)-Tyrphostin 46; (E)-Tyrphostin AG 99) 是有效的 EGFR 抑制剂。

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(E)-AG 99 Chemical Structure

(E)-AG 99 Chemical Structure

CAS No. : 122520-85-8

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Size Price Stock Quantity
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ¥1210 In-stock
10 mg ¥1100 In-stock
50 mg ¥3600 In-stock
100 mg ¥6100 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

(E)-AG 99 ((E)-Tyrphostin 46; (E)-Tyrphostin AG 99) is a potent EGFR inhibitor[1].

IC50 & Target[1]

EGFR

 

In Vitro

(E)-AG 99 effectively blocks tyrosine phosphorylation of p145met and promotes cell death accompanied by activation of caspase-like proteases[1].

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 165 mg/mL (808.11 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.8976 mL 24.4882 mL 48.9764 mL
5 mM 0.9795 mL 4.8976 mL 9.7953 mL
10 mM 0.4898 mL 2.4488 mL 4.8976 mL
*请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液。
In Vivo:
  • 1.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.75 mg/mL (13.47 mM); Clear solution

  • 2.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.75 mg/mL (13.47 mM); Clear solution

*以上所有助溶剂都可在 MCE 网站选购。
References
Molecular Weight

204.18

Formula

C₁₀H₈N₂O₃

CAS No.

122520-85-8

SMILES

O=C(N)/C(C#N)=C/C1=CC=C(O)C(O)=C1.[(E)]

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
(E)-AG 99
目录号:
HY-100962
需求量:

(E)-AG 99

Cat. No.: HY-100962