1. Cell Cycle/DNA Damage
    PI3K/Akt/mTOR
  2. DNA-PK
  3. (R)-Nedisertib

(R)-Nedisertib (Synonyms: (R)-M3814)

目录号: HY-101570A
产品使用指南

(R)-Nedisertib ((R)-M3814) 是一种活性较弱的 Nedisertib 的 R 型异构体,对 DNA-PKIC50 值为 7-30 nM。

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(R)-Nedisertib Chemical Structure

(R)-Nedisertib Chemical Structure

CAS No. : 1637542-32-5

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Size Price Stock Quantity
10 mM * 1 mL in DMSO ¥2750 In-stock
5 mg ¥2500 In-stock
10 mg ¥3500 In-stock
25 mg ¥6500 In-stock
50 mg ¥9500 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Description

(R)-Nedisertib ((R)-M3814) is a less active R-enantiomer of Nedisertib, with an IC50 in the range of 7-30 nM for DNA-PK[1].

IC50 & Target[1]

DNA-PK

7-30 nM (IC50)

In Vitro

Rac-Nedisertib (Compound 135) less actively inhibits DNA-PK, with an IC50 in the range of 7-30 nM[1].

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (207.51 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0751 mL 10.3754 mL 20.7508 mL
5 mM 0.4150 mL 2.0751 mL 4.1502 mL
10 mM 0.2075 mL 1.0375 mL 2.0751 mL
* 请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液,并请注意储备液的保存方式和期限。
In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案,配制前请先配制澄清的储备液,再依次添加助溶剂 (为保证实验结果的可靠性,体内实验的工作
液,建议您现用现配,当天使用;澄清的储备液可以根据储存条件,适当保存;以下溶剂前的百分比是指该溶剂在您配制终溶液中的体积占比):

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.19 mM); Clear solution

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.19 mM); Clear solution

*以上所有助溶剂都可在 MCE 网站选购。
References
Molecular Weight

481.91

Formula

C₂₄H₂₁ClFN₅O₃

CAS No.

1637542-32-5

SMILES

ClC1=C([C@@H](O)C2=NN=C(OC)C=C2)C=C(C3=C4C=CC(N5CCOCC5)=CC4=NC=N3)C(F)=C1

Shipping

Room temperature in continental US; may vary elsewhere

  • 摩尔计算器

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
(R)-Nedisertib
目录号:
HY-101570A
需求量:

(R)-Nedisertib

Cat. No.: HY-101570A