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(±)-CPSI-1306 

目录号: HY-110095 纯度: 98.50%
产品使用指南

(±)-CPSI-1306 是具有口服活性的、巨噬细胞游走因子 (MIF) 的拮抗剂。

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(±)-CPSI-1306 Chemical Structure

(±)-CPSI-1306 Chemical Structure

CAS No. : 1309793-47-2

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Size Price Stock Quantity
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ¥1320 In-stock
5 mg ¥1200 In-stock
10 mg ¥1900 In-stock
25 mg ¥3900 In-stock
50 mg ¥6600 In-stock
100 mg ¥11000 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

(±)-CPSI-1306 is an orally available antagonist of macrophage migration inhibitory factor (MIF).

IC50 & Target

MIF[1].

In Vivo

Mice treated with CPSI-1306 show a significant drop in their blood glucose levels, which is associated with a reduction in serum levels of inflammatory cytokines. As expected, control mice treated with vehicle develop NIDDM as characterized by high serum levels of glucose and inflammatory cytokine. Furthermore, they also show that orally bioavailable CPSI-1306 can be effective in treating this disease[1]. CPSI-1306-induced keratinocyte apoptosis could be appreciated as early as 30 minutes after a single UVB exposure. At 6, 24, and 48 hours following UVB exposure, the CPSI-1306-treated mice show significantly increased expression of cleaved caspase-3 compared with the vehicle-treated mice. CPSI-1306 reduces acute UVB-induced keratinocyte DNA damage and UVB-induced acute inflammation[2].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2227 mL 16.1134 mL 32.2269 mL
5 mM 0.6445 mL 3.2227 mL 6.4454 mL
10 mM 0.3223 mL 1.6113 mL 3.2227 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[1]

Mice[1]
Six- to 8-wk-old female BALB/c mice and ICR mice are used in the study. Age- and sex-matched ICR mice are deprived of food for 20 h and then injected intraperitoneally with STZ (90 mg/kg). Beginning at 6 h after STZ injection, mice are administered CPSI-1306 (1 or 0.1 mg/kg) or PBS daily in a single oral dose for 30 d[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

310.30

Formula

C₁₅H₁₆F₂N₂O₃

CAS No.

1309793-47-2

SMILES

FC1=C(C=CC(F)=C1)C2=NOC(CC(N3CCOCC3)=O)C2

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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产品名称:
(±)-CPSI-1306
目录号:
HY-110095
需求量:

(±)-CPSI-1306

Cat. No.: HY-110095