1. Neuronal Signaling
  2. Amyloid-β
  3. β-Amyloid (1-16)

β-Amyloid (1-16)  (Synonyms: Amyloid β-Protein (1-16))

目录号: HY-P1466 纯度: 99.98%
COA 产品使用指南

β-Amyloid (1-16) 是可参与金属结合的β-淀粉样蛋白片段。 β-淀粉样蛋白是在阿尔茨海默病患者的脑中形成淀粉样斑块的肽。

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Custom Peptide Synthesis

β-Amyloid (1-16) Chemical Structure

β-Amyloid (1-16) Chemical Structure

CAS No. : 131580-10-4

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

β-Amyloid (1-16) is a β-Amyloid protein fragment involved in metal binding. Beta-amyloid is a peptide that forms amyloid plaques in the brains of Alzheimer's disease (AD) patients.

IC50 & Target

Amyloid-β[1]

体内研究
(In Vivo)

β-amyloid (1-16) fragment is considered as valid models to examine the contribution of the key histidine residues (His , His in mouse and His , His , His in human fragments) to the Ab–Cu2+ interaction. Oxidation targets for β-Amyloid (1-16) are the histidine residues coordinated to the metal ions. Copper is bound to Aβ in senile plaque of Alzheimer’s disease with β-Amyloid (1-16) taking part in the coordination of the Cu2+ ions. Cu2+ and Zn2+ are linked with the neurotoxicity of -Amyloid and free radical damage[1]. β-amyloid (1-16) is the minimal amino acidic sequence display a Cu coordination mode which involves three Histidines (His6, His13 and His14). β-amyloid (1-16) is supposed to be involved in metal binding[2]. Human β-amyloid interacts with zinc ions through its metal-binding domain 1-16. The C-tails of the two polypeptide chains of the rat Aβ(1-16) dimer are oriented in opposite directions to each other, which hinders the assembly of rat Aβ dimers into oligomeric aggregates. Thus, the differences in the structure of zinc-binding sites of human and rat β-Amyloid (1-16), their ability to form regular cross-monomer bonds, and the orientation of their hydrophobic C-tails could be responsible for the resistance of rats to Alzheimer's disease[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1955.01

Formula

C84H119N27O28

CAS 号
性状

固体

颜色

White to off-white

Sequence

Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys

Sequence Shortening

DAEFRHDSGYEVHHQK

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*该产品在溶液状态不稳定,建议您现用现配,即刻使用。

纯度 & 产品资料

纯度: 99.98%

参考文献

β-Amyloid (1-16) 相关分类

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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