1. Neuronal Signaling
  2. Beta-secretase

β-Secretase Inhibitor IV (Synonyms: Axon 1125)

目录号: HY-10133
产品使用指南

β-Secretase Inhibitor IV 是一种有效的具有细胞活性的 BACE-1 抑制剂,在 BACE-1 浓度分别为 2 nM 和 100 pM 时,IC50 分别为 15.6 和 16.3 nM。

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β-Secretase Inhibitor IV Chemical Structure

β-Secretase Inhibitor IV Chemical Structure

CAS No. : 797035-11-1

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Description

β-Secretase Inhibitor IV is a potent, cell-active BACE-1 inhibitor with IC50s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively.

IC50 & Target

IC50: 15.3±0.6 nM (BACE-1), 230±26 nM (BACE-2), 7620±210 nM (Cathepsin D)[1]

In Vitro

In the cell culture assay, β-Secretase Inhibitor IV (Compound 2) inhibits the production of Aβ peptides with an EC50 of 43 nM. β-Secretase Inhibitor IV potently suppresses the secretion of sAPP_NF and EV40 from HEK293T cells with an IC50 near 30 nM[1].

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 1.7280 mL 8.6398 mL 17.2795 mL
5 mM 0.3456 mL 1.7280 mL 3.4559 mL
10 mM 0.1728 mL 0.8640 mL 1.7280 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

578.72

Formula

C₃₁H₃₈N₄O₅S

CAS No.

797035-11-1

SMILES

O=S(N(C)C1=CC(C(N[C@@H](CC2=CC=CC=C2)[C@H](O)CNC3CC3)=O)=CC(C(N[C@H](C)C4=CC=CC=C4)=O)=C1)(C)=O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
β-Secretase Inhibitor IV
目录号:
HY-10133
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