2. 抗体抑制剂
  3. Biosimilar 抗体
  4. 单克隆抗体
  5. Atigotatug (FUT8-KO)

Atigotatug (FUT8-KO)  (Synonyms: BMS-986012 (FUT8-KO))

目录号: HY-P990902A
技术支持

Atigotatug (FUT8-KO) 是敲除了岩藻糖基转移酶 8 基因 (FUT8) 的 CHO 细胞表达的抗 fuc-GM1 单克隆抗体，岩藻糖缺失增强了抗体的 ADCC 效应。Atigotatug (HY-P990902) 是一种靶向岩藻糖神经节苷脂 GM1 (fuc-GM1) 的 IgG1κ 型人源化抗体。Atigotatug 可诱导免疫介导的肿瘤细胞死亡，例如小细胞肺癌。

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Atigotatug (FUT8-KO) Chemical Structure

Atigotatug (FUT8-KO) Chemical Structure

CAS No. : 2733581-82-1

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Other Forms of Atigotatug (FUT8-KO):

Atigotatug (FUT8-KO) 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Atigotatug (FUT8-KO) is an anti-fuc-GM1 monoclonal antibody expressed by CHO cells with the fucosyltransferase 8 gene (FUT8) knocked out, and fucose deficiency enhances the ADCC effect of the antibody. Atigotatug (HY-P990902) is a Fucosyl ganglioside GM1 (fuc-GM1)-targeting IgG1κ type humanized antibody. Atigotatug can induce immune-mediated tumor cell death, such as small cell lung cancer[1].

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储存方式

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纯度 & 产品资料
参考文献

Atigotatug (FUT8-KO) 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Atigotatug (FUT8-KO)2733581-82-1BMS-986012 (FUT8-KO)OthersFucosyltransferase 8 geneFUT8Fucosyl ganglioside GM1Fuc-GM1Inhibitorinhibitorinhibit

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