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  3. Ceftriaxone sodium hydrate

Ceftriaxone sodium hydrate  (Synonyms: 头孢曲松钠水合物; Ro 13-9904 sodium hydrate)

目录号: HY-B0712A 纯度: 98.03%
COA 产品使用指南

Ceftriaxone sodium hydrate (Ro 13-9904 sodium hydrate) 是一种广谱 β-内酰胺类三代头孢菌素类抗生素,对多种革兰氏阴性菌和阳性菌有良好的抗菌活性。Ceftriaxone sodium hydrate 是 GSK3β 的共价抑制剂,IC50 值为 0.78 μM。 Ceftriaxone sodium hydrate 是 Aurora B 的抑制剂。Ceftriaxone sodium hydrate 具有抗炎、抗肿瘤和抗氧化活性。Ceftriaxone sodium hydrate 可用于治疗细菌性感染和脑膜炎的研究。

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Ceftriaxone sodium hydrate Chemical Structure

Ceftriaxone sodium hydrate Chemical Structure

CAS No. : 104376-79-6

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100 mg ¥530
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生物活性

Ceftriaxone sodium hydrate (Ro 13-9904 sodium hydrate) is a broad spectrum β-lactam third-generation cephalosporin antibiotic, which has good antibacterial activity against a variety of gram-negative and positive bacteria. Ceftriaxone sodium hydrate is a covalent inhibitor of GSK3β with IC50 value of 0.78 μM. Ceftriaxone sodium hydrate is an inhibitor of Aurora B. Ceftriaxone sodium hydrate has anti-inflammatory, antitumor and antioxidant activities. Ceftriaxone sodium hydrate can be used in the study of bacterial infections and meningitis[1][2][3][4][5][6][7].

IC50 & Target

β-lactam

 

体外研究
(In Vitro)

Ceftriaxone sodium hydrate (100 μM, 24 h) 通过抑制 NF-κB /JNK/c-Jun 信号通路保护被 MPP+ 处理的星形细胞[3]
Ceftriaxone sodium hydrate (500 μM, 24-48 h) 通过抑制极光激酶 B (Aurora B) 有效抑制 A549、H520 和H1650 肺癌细胞的非锚定细胞生长[4]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[3]

Cell Line: Astrocyte
Concentration: 100 μM
Incubation Time: 24 h
Result: Improved cell viability and increased glutamate uptake after MPP+ expose.

Western Blot Analysis[3]

Cell Line: Astrocyte
Concentration: 100 μM
Incubation Time: 24 h
Result: Enhanced GLT-1 and GFAP expression.
Decreased the expression of p-p50、p-IKKα、p-Relb.
Decreased the number of TUNEL-positive cells.
体内研究
(In Vivo)

Ceftriaxone sodium hydrate (200 mg/kg, 腹腔注射, 连续 6 周) 在 D-半乳糖 (DGL) 诱导的大鼠肝肾损伤模型中可改善功能指标,以及氧化应激和炎症参数[5]
Ceftriaxone sodium hydrate (200, 400 mg/kg, 腹腔注射) 对大鼠 Pentylenetetrazol (PTZ) 致惊厥及PTZ 相关氧化损伤具有保护作用[6]
Ceftriaxone sodium hydrate (100, 200 mg/kg, 腹腔注射) 在 Streptozocin (HY-13753) 诱导的糖尿病大鼠模型中通过激活 GLT-1 减少机械性异常性痛和痛觉过敏[7]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: DGL-induced rat model[5]
Dosage: 200 mg/kg
Administration: i.p.
Result: Reduced the BUN、Cr 、AST and ALT levels.
Attenuated the MDA levels and enhanced GPx and CAT activities.
Reduced the levels of IL-1β and TNF-α mRNA.
Animal Model: PTZ-induced rat model[6]
Dosage: 200, 400 mg/kg
Administration: i.p. 60 min before to PTZ (70 mg/kg)
Result: Both of the two ceftriaxone groups had lower spike percentages than the saline group.
Significantly lower MDA levels and higher SOD activity in 200 and 400 mg/kg.
Clinical Trial
分子量

661.60

Formula

C18H23N8Na2O10.5S3

CAS 号
性状

固体

颜色

White to off-white

中文名称

头孢曲松钠水合物

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

纯度 & 产品资料
参考文献
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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