2. Epigenetics
  3. Histone Methyltransferase
  4. CPUY074020

CPUY074020 是一种高效、有口服活性的组蛋白甲基转移酶 G9a 抑制剂，其 IC50 值为 2.18 μM。CPUY074020 具有抗增殖活性。

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CPUY074020 Chemical Structure

CPUY074020 Chemical Structure

CAS No. : 902279-44-1

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规格 价格 是否有货 数量
1 mg ￥2205
1 周
5 mg   询价  
10 mg   询价  

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Customer Review

CPUY074020 相关抗体

Top Publications Citing Use of Products

查看 Histone Methyltransferase 亚型特异性产品:

查看所有亚型
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CPUY074020 is a potent and oral bioavailable inhibitor of histone methyltransferase G9a, with an IC50 of 2.18 μM. CPUY074020 possesses anti-proliferative activity[1].

IC50 & Target

IC50: 2.18 μM (G9a)[1]
体外研究
(In Vitro)

CPUY074020 (2-8μM; 24 hours) induces cell death through apoptosis[1].
CPUY074020 (2.5-10μM ; 48 hours) dose-dependently de-regulates H3K9 trimethylation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CPUY074020 相关抗体:

Apoptosis Analysis[1]

Cell Line: MCF-7 cells
Concentration: 2 μM, 4 μM, 8 μM
Incubation Time: 24 hours
Result: Induced MCF-7 cells apoptosis.

Western Blot Analysis[1]

Cell Line: MCF-7 cells
Concentration: 2.5 μM, 5 μM, 10 μM
Incubation Time: 48 hours
Result: Dose-dependently de-regulated H3K9 trimethylation.
体内研究
(In Vivo)

CPUY074020 exhibits reasonable PK properties, with an oral bioavailability of 55.5% and a T1/2 value of 4.0 hours at an oral dose of 10 mg/kg[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice
Dosage: 10 mg/kg
Administration: Oral administration
Result: t1/2=4.0 hours
分子量

416.52

Formula

C25H28N4O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CPUY074020 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CPUY074020902279-44-1CPUY 074020CPUY-074020Histone MethyltransferaseProteinlysinemethyltransferaseG9aInhibitorinhibitorinhibit

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产品名称：
CPUY074020
目录号：
HY-100757
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