1. Anti-infection
  2. Bacterial Antibiotic
  3. Delafloxacin

Delafloxacin  (Synonyms: 德拉沙星; RX-3341; WQ-3034; ABT492)

目录号: HY-14814 纯度: 99.84%
COA 产品使用指南

Delafloxacin (RX-3341; WQ-3034; ABT492) 是一种广谱氟喹诺酮类抗生素。Delafloxacin 具有广泛的活性,对耐药性的金黄色葡萄球菌,肺炎链球菌和肺炎克雷伯菌都有效。

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Delafloxacin Chemical Structure

Delafloxacin Chemical Structure

CAS No. : 189279-58-1

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥343
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5 mg ¥312
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10 mg ¥500
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50 mg ¥2000
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Other Forms of Delafloxacin:

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Delafloxacin (RX-3341; WQ-3034; ABT492) is a broad-spectrum fluoroquinolone antibiotic. Delafloxacin has a broad spectrum of activity that includes drug-resistant Staphylococcus aureus, Streptococcus pneumoniae, and Klebsiella pneumonia[1].

IC50 & Target

Quinolone

 

体内研究
(In Vivo)

Delafloxacin (the total daily doses vary from 0.156 to 640 mg/kg/24 h, subcutaneous injection) is highly effective against S. aureus. Against all four strains are observed a decrease of 1.5 to 2.2 log10 CFU in organism burden from untreated controls at even the lowest dose studied, and for two strains (MW2 and R2527) there is net bactericidal activity at the lowest dose. At the maximal doses studied, there is a >4-log10 kill from initial burden for all S. aureus strains[1].
Delafloxacin (2.5, 10, 40, and 160 mg/kg; subcutaneous injection, 24 h) has moderate terminal elimination half-life (t1/2=0.68 h, 0.79 h, 0.69 h and 1.0 h for 2.5 mg/kg, 10 mg/kg, 40 mg/kg, and 160 mg/kg, respectively)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice with a neutropenic murine lung infection model (four S. aureus , four S. pneumoniae, and four K. pneumoniae strains)[1]
Dosage: The total daily doses vary from 0.156 to 640 mg/kg/24 h
Administration: 0.03 to 160 mg/kg are administered every 6 h (q6h) to infected mice by subcutaneous injection
Result: Inhibited S. aureus strains ATCC 29213, ATCC 33591, MW2, R2527 with MICs of 0.008, 0.008, 0.004, and 0.004 mg/L, respectively.
Inhibited S. pneumoniae strains ATCC 10813, ATCC 49619, 145, and 1329 with MICs of 0.03, 0.125, 0.016, and 0.016 mg/L, respectively.
Inhibited K. pneumonia strains ATCC 43816, 4105, 4110, and 81-1260A with MICs of 0.06, 1, 0.5, and 0.06 mg/L, respectively.
Animal Model: Neutropenic mice[1]
Dosage: 2.5, 10, 40, and 160 mg/kg; 0.2 mL
Administration: Subcutaneous injection; 24 h
Result: The maximum drug concentrations (Cmax) concentrations ranged from 2 to 71 mg/L. AUC0-∞ values ranged from 2.8 to 152 mg•h/L and were linear across the 2.5- to 160-mg dosing range. The elimination half-life (t1/2) ranged from 0.7 to 1 h.
Clinical Trial
分子量

440.76

Formula

C18H12ClF3N4O4

CAS 号
性状

固体

颜色

Off-white to light yellow

中文名称

德拉沙星

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 100 mg/mL (226.88 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.2688 mL 11.3440 mL 22.6881 mL
5 mM 0.4538 mL 2.2688 mL 4.5376 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Delafloxacin 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2688 mL 11.3440 mL 22.6881 mL 56.7202 mL
5 mM 0.4538 mL 2.2688 mL 4.5376 mL 11.3440 mL
10 mM 0.2269 mL 1.1344 mL 2.2688 mL 5.6720 mL
15 mM 0.1513 mL 0.7563 mL 1.5125 mL 3.7813 mL
20 mM 0.1134 mL 0.5672 mL 1.1344 mL 2.8360 mL
25 mM 0.0908 mL 0.4538 mL 0.9075 mL 2.2688 mL
30 mM 0.0756 mL 0.3781 mL 0.7563 mL 1.8907 mL
40 mM 0.0567 mL 0.2836 mL 0.5672 mL 1.4180 mL
50 mM 0.0454 mL 0.2269 mL 0.4538 mL 1.1344 mL
60 mM 0.0378 mL 0.1891 mL 0.3781 mL 0.9453 mL
80 mM 0.0284 mL 0.1418 mL 0.2836 mL 0.7090 mL
100 mM 0.0227 mL 0.1134 mL 0.2269 mL 0.5672 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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