2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. Dexpramipexole

Dexpramipexole  (Synonyms: 右旋普拉克索; (R)-Pramipexole; R-(+)-Pramipexole; KNS-760704)

目录号: HY-17355B
产品使用指南

摩尔计算器

Dexpramipexole(KNS-760704)也叫R-(+)-Pramipexole，是神经保护剂，是弱的非麦角类多巴胺受体激动剂。

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Dexpramipexole Chemical Structure

Dexpramipexole Chemical Structure

CAS No. : 104632-28-2

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Dexpramipexole 的其他形式现货产品:

Dexpramipexole 相关抗体

Top Publications Citing Use of Products

    Dexpramipexole purchased from MCE. Usage Cited in: Neuroreport. 2023 Jan 23.  [Abstract]

    Dexpramipexole (DPX; 3 mg/kg; i.p.; once daily for 6 consecutive days) attenuates the LPS-induced increase in the number of TUNEL-positive cells in the hippocampus in SAE mice.

    Dexpramipexole purchased from MCE. Usage Cited in: Neuroreport. 2023 Jan 23.  [Abstract]

    Dexpramipexole (DPX; 3 mg/kg; i.p.; once daily for 6 consecutive days) attenuates LPS-induced activation of microglia and astrocytes in the hippocampus in SAE mice. (a) Representative images of Iba-1 staining and quantification of Iba-1 (green) fluorescence intensity in the hippocampal CA1 and DG regions. (b) Representative images of GFAP staining and quantification of GFAP (red) fluorescence intensity in the hippocampal CA1 and DG regions. DAPI staining is shown in blue.

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    Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Dexpramipexole(KNS-760704), also known as R-(+)-Pramipexole, is a neuroprotective agent and weak non-ergoline dopamine agonist. IC50 Value: Target: Dopamine Receptor Dexpramipexole has been found to have neuroprotective effects and is being investigated for treatment of amyotrophic lateral sclerosis (ALS). Dexpramipexole reduces mitochondrial reactive oxygen species (ROS) production, inhibits the activation of apoptotic pathways, and increase cell survival in response to a variety of neurotoxins and β-amyloid neurotoxicity. Compared to the S-(-) isomer, Dexpramipexole has much lower dopamine agonist activity.

    Clinical Trial
    分子量

    211.33

    Formula

    C10H17N3S
    CAS 号
    中文名称

    右旋普拉克索
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    Dexpramipexole 相关分类

    • 摩尔计算器

    • 稀释计算器

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量   浓度   体积   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Dexpramipexole104632-28-2(R)-Pramipexole R-(+)-Pramipexole KNS-760704右旋普拉克索KNS760704KNS 760704KNS-760704Dopamine ReceptorInhibitorinhibitorinhibit

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