1. GPCR/G Protein Neuronal Signaling
  2. Adrenergic Receptor
  3. Arformoterol

Arformoterol  (Synonyms: 福莫特罗; (R,R)-Formoterol)

目录号: HY-B0010A 纯度: ≥98.0%
COA 产品使用指南

Arformoterol ((R,R)-Formoterol) 是 Formoterol 的 (R,R)-对映异构体,是一种长效 β2-肾上腺素能受体 (β2-AR) 激动剂,Kd 为 2.9 nM。Arformoterol 可用于慢性阻塞性肺疾病 (COPD) 的研究。

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Arformoterol Chemical Structure

Arformoterol Chemical Structure

CAS No. : 67346-49-0

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  • 生物活性

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生物活性

Arformoterol ((R,R)-Formoterol), the (R,R)-enantiomer of Formoterol, is a long-acting β2-adrenergic receptor (β2-AR) agonist, with a Kd of 2.9 nM. Arformoterol can be used for the research of chronic obstructive pulmonary disease (COPD)[1][2].

IC50 & Target[1]

Beta-2 adrenergic receptor

2.9 nM (Kd)

体外研究
(In Vitro)

Arformoterol induces cAMP accumulation in cultured human bronchial epithelial cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Arformoterol (10 ng in 0.1 ml saline/20 g body weight; intranasal instillation) mitigates Cl2-induced increases of respiratory system resistance and elastance in mice[3].
Arformoterol reverses histamine- and ovalbumin-induced bronchoconstriction in guinea pigs (ED50s=1 and 40 nmol/kg, respectively)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wild-type and iNOS−/− mice were exposed to Cl2 gas[3]
Dosage: 10 ng in 0.1 ml saline/20 g body weight
Administration: Intranasal instillation in the external nares at 10 minutes and every 24 hours after exposure
Result: Significantly mitigated the Cl2-induced increases of respiratory system resistance and elastance.
Increased cAMP in the lungs of Cl2-exposed mice.
Not mitigated Cl2-induced lung injury and inflammation.
分子量

344.40

Formula

C19H24N2O4

CAS 号
性状

固体

颜色

White to off-white

中文名称

福莫特罗

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料

纯度: 99.96%

参考文献
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Arformoterol
目录号:
HY-B0010A
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