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  2. Ccr4 - chemokine (C-C motif) receptor 4 Gene

Ccr4 - chemokine (C-C motif) receptor 4 Gene

中文名称:趋化因子 (CC 基序) 受体 4

种属: Mus musculus

同用名: LESTR; Sdf1r; CHEMR1; Cmkbr4; C-C CKR-4

基因 ID: 12773 | 基因类型: protein coding

关于 Ccr4

Chromosome 9: 114,319,384-114,333,984 reverse strand.GRCm39:CM001002.3

This gene has 3 transcripts (splice variants), 114 orthologues, 25 paralogues and is associated with 29 phenotypes. Biased expression in thymus adult (RPKM 1.4), testis adult (RPKM 1.5) and 2 other tissues.

功能概要

该基因编码的蛋白可启动 CC 趋化因子受体活性。作用于多个过程的上游或内部,包括细胞数量的稳态;神经元迁移;和耐受诱导。位于质膜外侧。以多种结构表达,包括中枢神经系统;肠;幽门窦;生殖系统;和胸腺。与人 CCR4(CC 基序趋化因子受体 4)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables C-C Chemokine Receptor activity. Acts upstream of or within several processes, including homeostasis of number of cells; neuron migration; and tolerance induction. Located in external side of plasma membrane. Is expressed in several structures, including central nervous system; intestine; pyloric antrum; reproductive system; and thymus. Orthologous to human CCR4 (C-C motif Chemokine Receptor 4). [provided by Alliance of Genome Resources, Apr 2022]

Ccr4 基因产物(2)

mRNA Protein Name
NM_009916.2 NP_034046.2 C-C chemokine receptor type 4
NM_009916.2 NP_034046.2 C-C chemokine receptor type 4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables C-C chemokine receptor activity IMP
IMP: 通过突变表型推断
10811868 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within chemotaxis IMP
IMP: 通过突变表型推断
10811868 MGI
acts upstream of or within homeostasis of number of cells IMP
IMP: 通过突变表型推断
24069263 MGI
acts upstream of or within inflammatory response IMP
IMP: 通过突变表型推断
10811868 MGI
acts upstream of or within interneuron migration IMP
IMP: 通过突变表型推断
16262623 MGI
acts upstream of or within neuron migration IMP
IMP: 通过突变表型推断
16262623 MGI
acts upstream of or within tolerance induction IMP
IMP: 通过突变表型推断
15809349 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
19008373 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Ccr4 蛋白结构

7tmA_Chemokine_R

7tmA_Chemokine_R: cd14984 (39 - 66)

7tmA_Chemokine_R

7tmA_Chemokine_R: cd14984 (39 - 314)

7tmA_Chemokine_R

7tmA_Chemokine_R: cd14984 (73 - 98)

7tmA_Chemokine_R

7tmA_Chemokine_R: cd14984 (109 - 139)

7tmA_Chemokine_R

7tmA_Chemokine_R: cd14984 (153 - 173)

7tmA_Chemokine_R

7tmA_Chemokine_R: cd14984 (198 - 227)

7tmA_Chemokine_R

7tmA_Chemokine_R: cd14984 (234 - 264)

7tmA_Chemokine_R

7tmA_Chemokine_R: cd14984 (282 - 307)

  • 0
  • 100
  • 200
  • 300
  • 360 a.a.
蛋白主名 其他名称

C-C chemokine receptor type 4

chemokine (C-C) receptor 4

fusin

leukocyte-expressed seven-transmembrane-domain receptor

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ccr4 NCBI NCBI:1233