2. Gene
  3. TRIM35 - tripartite motif containing 35 Gene

TRIM35 - tripartite motif containing 35 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含三方基序 35

种属: Homo sapiens

同用名: HLS5; MAIR

基因 ID: 23087 | 基因类型: protein coding

关于 TRIM35

Cytogenetic location: 8p21.2 Genomic coordinates (GRCh38): 8:27,284,886-27,311,272 (from NCBI)

This gene has 4 transcripts (splice variants), 121 orthologues and 80 paralogues. Ubiquitous expression in skin (RPKM 5.7), testis (RPKM 5.1) and 25 other tissues.

功能概要

由该基因编码的蛋白质是三联基序 (TRIM) 家族的成员。 TRIM 基序包括三个锌结合域、一个 RING、一个 B-box 类型 1 和一个 B-box 类型 2，以及一个卷曲螺旋区域。这种蛋白质的功能尚未确定。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The function of this protein has not been identified. [provided by RefSeq, Jul 2008]

TRIM35 基因产物(3)

mRNA Protein Name
NM_001304495.2 NP_001291424.1 E3 ubiquitin-protein ligase TRIM35 isoform 2
NM_001362813.2 NP_001349742.1 E3 ubiquitin-protein ligase TRIM35 isoform 3
NM_171982.5 NP_741983.2 E3 ubiquitin-protein ligase TRIM35 isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in innate immune response IDA
IDA: 通过直接分析推断
18248090 GOA
involved in negative regulation of mitotic cell cycle IDA
IDA: 通过直接分析推断
14662771 GOA
involved in positive regulation of apoptotic process IDA
IDA: 通过直接分析推断
14662771 GOA
involved in suppression of viral release by host IDA
IDA: 通过直接分析推断
18248090 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TRIM35 蛋白结构

zf-C3HC4_2

zf-C3HC4_2: Zinc finger, C3HC4 type (RING finger) (21 - 60)

zf-B_box

zf-B_box: B-box zinc finger (99 - 137)

PRY

PRY: SPRY-associated domain (305 - 351)

SPRY

SPRY: SPRY domain (353 - 468)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 493 a.a.
蛋白主名 其他名称

E3 ubiquitin-protein ligase TRIM35

hemopoietic lineage switch protein 5

关联疾病

疾病名称 别名
Hypotrichosis-Lymphedema-Telangiectasia-Renal Defect Syndrome

Glomerulonephritis With Sparse Hair And Telangiectases

Telangiectatic Membranoproliferative Glomerulonephritis

HLTRS

Hypotrichosis-Lymphedema-Telangiectasia-Membranoproliferative Glomerulonephritis Syndrome

Hlt-Renal Defect Syndrome

Glomerulonephritis Sparse Hair Telangiectases
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15039 TRIM35 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS21209 Trim35 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS27725 Trim35 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta TRIM35 VGNC VGNC:79026
Rattus norvegicus TRIM35 RGD RGD:1564642
Felis catus TRIM35 VGNC VGNC:66535
Canis familiaris TRIM35 VGNC VGNC:47816
Mus musculus TRIM35 MGD MGI:1914104
Bos taurus TRIM35 VGNC VGNC:36330
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