XCR1 - X-C motif chemokine receptor 1 Gene

中文名称：XC 基序趋化因子受体 1

种属: Homo sapiens

同用名: GPR5; CCXCR1

关于 XCR1

功能概要

该基因编码的蛋白质是属于 G 蛋白偶联受体超家族的趋化因子受体。该家族成员的特征在于存在 7 个跨膜结构域和大量保守氨基酸。该受体与 RBS11 和 MIP1-alpha/RANTES 受体关系最密切。它通过增加细胞内钙离子水平来转导信号。病毒巨噬细胞炎症蛋白-II 是该受体的拮抗剂并阻断信号传导。已针对该基因发现了几种编码相同蛋白质的可变剪接转录物变体。[RefSeq 提供，2020 年 4 月]

The protein encoded by this gene is a Chemokine Receptor belonging to the G protein-coupled receptor superfamily. The family members are characterized by the presence of 7 transmembrane domains and numerous conserved Amino acids. This receptor is most closely related to RBS11 and the MIP1-alpha/RANTES receptor. It transduces a signal by increasing the intracellular calcium ions level. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blocks signaling. Several alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Apr 2020]