2. Gene
  3. TRIM52 - tripartite motif containing 52 Gene

TRIM52 - tripartite motif containing 52 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含三方基序 52

种属: Homo sapiens

同用名: RNF102

基因 ID: 84851 | 基因类型: protein coding

关于 TRIM52

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:181,249,062-181,261,143 (from NCBI)

This gene has 10 transcripts (splice variants), 175 orthologues and 80 paralogues. Ubiquitous expression in lymph node (RPKM 9.5), spleen (RPKM 9.1) and 25 other tissues.

功能概要

启用转录共激活因子活性和泛素蛋白连接酶活性。参与多个过程，包括 I-kappaB 激酶/NF-kappaB 信号的正调控； NF-kappaB 转录因子活性的正调控；和蛋白质自身泛素化。位于细胞质和细胞核中。 [由基因组资源联盟提供，2022 年 4 月]

Enables transcription coactivator activity and ubiquitin protein Ligase activity. Involved in several processes, including positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of NF-kappaB transcription factor activity; and protein autoubiquitination. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

TRIM52 基因产物(5)

mRNA Protein Name
NM_001346048.2 NP_001332977.1 E3 ubiquitin-protein ligase TRIM52 isoform 2
NM_001346049.2 NP_001332978.1 E3 ubiquitin-protein ligase TRIM52 isoform 3
NM_001346050.2 NP_001332979.1 E3 ubiquitin-protein ligase TRIM52 isoform 4
NM_001346051.2 NP_001332980.1 E3 ubiquitin-protein ligase TRIM52 isoform 5
NM_032765.4 NP_116154.1 E3 ubiquitin-protein ligase TRIM52 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables transcription coactivator activity IDA
IDA: 通过直接分析推断
23077300 GOA
enables ubiquitin protein ligase activity IDA
IDA: 通过直接分析推断
27667714 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in defense response to virus IDA
IDA: 通过直接分析推断
27667714 GOA
involved in positive regulation of NF-kappaB transcription factor activity IDA
IDA: 通过直接分析推断
23077300 GOA
involved in positive regulation of canonical NF-kappaB signal transduction IDA
IDA: 通过直接分析推断
27667714 GOA
involved in protein autoubiquitination IDA
IDA: 通过直接分析推断
27667714 GOA
involved in protein ubiquitination IDA
IDA: 通过直接分析推断
27667714 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
28073078 GOA
located in cytosol IDA
IDA: 通过直接分析推断
27667714 GOA
located in nucleus IDA
IDA: 通过直接分析推断
27667714 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TRIM52 蛋白结构

zf-C3HC4_4

zf-C3HC4_4: zinc finger of C3HC4-type, RING (20 - 54)

zf-B_box

zf-B_box: B-box zinc finger (223 - 263)

  • 0
  • 100
  • 200
  • 297 a.a.
蛋白主名 其他名称

E3 ubiquitin-protein ligase TRIM52

RING finger protein 102

关联疾病

疾病名称 别名
Japanese Encephalitis

Japanese B Encephalitis

Je

Encephalitis Japanese

Encephalitis, Japanese

Russian Autumnal Encephalitis

Je - [Japanese Encephalitis]

Japanese Encephalitis Virus Disease

Jbe - [Japanese B Encephalitis}

B Type Encephalitis
Encephalitis

Mumps Encephalitis

Mumps Meningoencephalitis

Herpes Simplex Neuroinvasion

Herpetic Encephalitis

Herpetic Encephalopathy

Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis

Encephalitis Due To Herpesviridae

Encephalitis Due To Herpesvirus

Herpes Encephalitis

Herpesviral Encephalitis

Herpes Simplex Encephalitis

Hsv - [Herpes Simplex Virus] Encephalitis

Herpes Virus Encephalitis

Simian B Disease

Simian B Disorder

Encephalitis Nec

Idiopathic Encephalitis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15054 TRIM52 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta TRIM52 VGNC VGNC:79172
Mus musculus TRIM52 MGD MGI:3045276
Canis familiaris TRIM52 VGNC VGNC:59045
Bos taurus TRIM52 VGNC VGNC:58617
Rattus norvegicus TRIM52 RGD RGD:1565615
Felis catus TRIM52 VGNC VGNC:102354
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