Guanfacine  (Synonyms: 胍法辛)

Guanfacine is an orally active noradrenergic α2A agonist and has high selective for the α2A receptor subtype. Guanfacine has effects in producing hypotension and sedation. Guanfacine can be used for the research of a variety of prefrontal cortex (PFC) cognitive disorders, including tourette's syndrome and attention deficit hyperactivity disorder (ADHD)^[1][2][3].

Guanfacine increases the delay-related neuronal firing needed for working memory on dIPFC neurons at the cellular level^[1][3].
Guanfacine improves PFC cognitive function by inhibiting the production of CAMP, closing HCN channels, and strengthening the PFC networks^[1][3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Guanfacine enhances PFC working memory function in aged monkeys and improves impulse control in monkeys performing a delayed discounting task^[1][3].
Guanfacine improves cognitive performance when infused directly into the rat or monkey PFC^[1][3].
Guanfacine blocks 2A receptors in the monkey dIPFC markedly impairs working memory, behavioral inhibition and greatly reduces persistent neuronal firing^[1][3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

246.09

C₉H₉Cl₂N₃O

29110-47-2

胍法辛；胍法新；氯苯乙胍

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Amy F T Arnsten, et al. Guanfacine for the treatment of cognitive disorders: a century of discoveries at Yale. Yale J Biol Med. 2012 Mar;85(1):45-58. Epub 2012 Mar 29.  [Content Brief]

  [2]. P. A. Van Zwieten, et al. The pharmacology of centrally acting antihypertensive drugs. Br J Clin Pharmacol. 1983; 15(Suppl 4): 455S–462S.

  [3]. Min Wang, et al. Alpha2A-adrenoceptors strengthen working memory networks by inhibiting cAMP-HCN channel signaling in prefrontal cortex. Cell. 2007 Apr 20;129(2):397-410.  [Content Brief]