1. GPCR/G Protein
  2. Protease-Activated Receptor (PAR)

I-191 

目录号: HY-117793
产品使用指南

I-191 是蛋白酶激活受体 2 (PAR-2) 信号通路的抑制剂。I-191 抑制 PAR-2 活化剂如 SLIGKV、胰蛋白酶、凝血酶,其 IC50 值分别为 0.0014 μM,0.0023 μM,0.32 μM,详细信息请参考专利WO2015048245A1。

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I-191 Chemical Structure

I-191 Chemical Structure

CAS No. : 1690172-25-8

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Description

I-191 is a protease-activated receptor 2 (PAR-2) signaling pathway inhibitor extracted from patent WO2015048245A1. I-191 inhibits PAR-2 activators such as SLIGKV, Trypsin, and Thrombin with IC50s of 0.0014 μM, 0.0023 μM, 0.32 μM, respectively[1].

IC50 & Target

IC50: 0.0014 μM (SLIGKV), 0.0023 μM (Trypsin), 0.32 μM (Thrombin)[1]

References
Molecular Weight

423.48

Formula

C₂₃H₂₆FN₅O₂

CAS No.

1690172-25-8

SMILES

O=C1NCCN(C(C2=CN3N=C(C4=CC=C(F)C=C4)C=C(C(C)(C)C)C3=N2)=O)C1(C)C

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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产品名称:
I-191
目录号:
HY-117793
需求量:

I-191

Cat. No.: HY-117793