2. Anti-infection Metabolic Enzyme/Protease Apoptosis
  3. HIV HIV Protease Apoptosis MMP SARS-CoV
  4. Indinavir

Indinavir  (Synonyms: 茚地那韦; MK-639 free base; L-735524 free base)

目录号: HY-B0689
产品使用指南

摩尔计算器

Indinavir (MK-639 free base) 是一种口服有效并且具有选择性的 HIV-1 蛋白酶抑制剂，其对PR 的 Ki 值为 0.54 nM。Indinavir 可通过抑制基质金属蛋白酶-2 水解的激活，抗血管生成以及促癌细胞凋亡来发挥抗癌活性。Indinavir 也是一种 SARS-CoV 3CLpro 抑制剂。

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Indinavir Chemical Structure

Indinavir Chemical Structure

CAS No. : 150378-17-9

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Indinavir 的其他形式现货产品:

Other Forms of Indinavir:

Indinavir 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Indinavir (MK-639 free base) is an orally active and selective HIV-1 protease inhibitor with a Ki of 0.54 nM for PR. Indinavir exhibits anticancer activity by inhibiting the activation of MMPs-2 hydrolysis, anti-angiogenesis and inducing apoptosis. Indinavir is also a SARS-CoV 3CLpro inhibitor[1][2][3][4].

IC50 & Target

HIV-1

 

MMP-2

 

体外研究
(In Vitro)

Indinavir (0-50 µM; 18 h) blocks lymphocyte cell cycle in G0/G1 phase in PBMCs cells and impairs lymphoproliferative responses[1].
Indinavir (40 µM-40 nM; 5 days) inhibits cell invasion and (40 µM-40 nM; 48 h) MMPs-2 activation of the Huh7 and SK-HEP-1 hepatocarcinoma cells in vitro[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Indinavir 相关抗体:

Cell Viability Assay[1]

Cell Line: PBMCs (from healthy and HIV-infected volunteers)
Concentration: 0-50 µM
Incubation Time: 18 h (pretreatment; stimulation with anti-CD3 for an additional 48 hours)
Result: Blocked anti-CD3-induced cell-cycle progression in a dose-dependent manner.
Resulted in dose-dependent reduction of lymphoproliferative responses.

Cell Invasion Assay[2]

Cell Line: Huh7 and SK-HEP-1 cells
Concentration: 40 µM-40 nM
Incubation Time: 5 days
Result: Reduced ability to invade an in vitro constituted extracellular matrix for both cell lines treated compared with the untreated cells.

Western Blot Analysis[2]

Cell Line: Huh7 and SK-HEP-1 cells
Concentration: 40 µM-40 nM
Incubation Time: 48 h
Result: Blocked the conversion of latent MMP-2 to its 62/64-kDa active form.
体内研究
(In Vivo)

Indinavir (70 mg/kg; i.g.; once a day for 3 weeks) inhibits the growth of hepatocarcinoma cells in vivo[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice(s.c. into Huh7 and SK-HEP-1 cells)[2].
Dosage: 70 mg/kg
Administration: Oral gavage; once a day for 3 weeks.
Result: Delaied the growth of s.c. implanted hepatocarcinoma xenografts in nude mice compared with placebo.
Clinical Trial
分子量

613.79

Formula

C36H47N5O4
CAS 号
中文名称

茚地那韦；吲地纳韦；英地那韦；印地那韦；茚地那维
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Indinavir 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Indinavir150378-17-9MK-639L-735524茚地那韦吲地纳韦英地那韦印地那韦茚地那维MK639MK 639L735524L 735524HIVHIV ProteaseApoptosisMMPSARS-CoVHuman immunodeficiency virusMatrix metalloproteinasesSARS coronavirusCD4 T cellsPBMChepatocarcinomasHuh7SK-HEP-1Inhibitorinhibitorinhibit

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