2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. KRAS G12C-IN-70

KRAS G12C-IN-70 是一种 KRAS G12C mutant 的选择性抑制剂。KRAS G12C-IN-70 阻断 KRAS G12C 介导的下游信号通路 (如 RAF-MEK-ERK)，抑制肿瘤细胞增殖。KRAS G12C-IN-70 有望用于 KRAS G12C 突变相关的肿瘤 (如非小细胞肺癌、结直肠癌) 的研究。

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KRAS G12C-IN-70 Chemical Structure

KRAS G12C-IN-70 Chemical Structure

CAS No. : 2923865-76-1

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KRAS G12C-IN-70 相关抗体

Top Publications Citing Use of Products

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K-Ras H-Ras N-Ras Ras

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

KRAS G12C-IN-70 is a selective KRAS G12C mutant inhibitor. KRAS G12C-IN-70 blocks KRAS G12C-mediated downstream signaling pathways (e.g., RAF-MEK-ERK) and inhibits tumor cell proliferation. KRAS G12C-IN-70 is promising for research of KRAS G12C mutation-related tumors (such as non-small cell lung cancer, colorectal cancer)[1].

IC50 & Target

KRAS(G12C)

 

分子量

552.98

Formula

C26H19ClF2N6O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

KRAS G12C-IN-70 相关分类

  • 摩尔计算器

  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KRAS G12C-IN-702923865-76-1RasKRAS G12C mutantRAF-MEK-ERKKRAS G12C mutation-related tumorsInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-174851
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