1. Anti-infection
  2. Influenza Virus

Laninamivir (Synonyms: R 125489)

目录号: HY-14818
产品使用指南

Laninamivir (R 125489) 是一种有效的流感神经氨酸酶 (NA) 抑制剂,其对流感病毒 H12N5 NA (N5),pH1N1 N1 NA (p09N1) 和 A/RI/5+/1957 H2N2 N2 (p57N2) 的 IC50 分别为 0.90 nM、1.83 nM 和 3.12 nM。

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Laninamivir Chemical Structure

Laninamivir Chemical Structure

CAS No. : 203120-17-6

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Description

Laninamivir (R 125489) is a potent influenza neuraminidase (NA) inhibitor with IC50s of 0.90 nM, 1.83 nM and 3.12 nM for avian H12N5 NA (N5), pH1N1 N1 NA (p09N1) and A/RI/5+/1957 H2N2 N2 (p57N2), respectively[1].

IC50 & Target

IC50: 0.90 nM (N5), 1.83 nM (p09N1), 3.12 nM (p57N2)[1]

In Vitro

Laninamivir inhibits efficiently common oseltamivir-resistant viruses, including those with the ubiquitous His274Tyr substitution[1].
Laninamivir is potent against p57N2, p09N1 and N5 with a similar binding mode to Zanamivir[1].

References
Molecular Weight

346.34

Formula

C₁₃H₂₂N₄O₇

CAS No.

203120-17-6

SMILES

OC[C@@H](O)[C@H]([C@@]1([H])[C@@H]([C@H](C=C(C(O)=O)O1)NC(N)=N)NC(C)=O)OC

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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产品名称:
Laninamivir
目录号:
HY-14818
需求量:

Laninamivir

Cat. No.: HY-14818