2. GPCR/G Protein
  3. GCGR GLP Receptor
  4. Liraglutide

Liraglutide  (Synonyms: 利拉鲁肽)

目录号: HY-P0014 纯度: 99.82%
COA 产品使用指南

摩尔计算器

Liraglutide 是一种胰高血糖素样肽-1 (GLP-1) 受体激动剂，用于研究 2 型糖尿病。

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Custom Peptide Synthesis

Liraglutide Chemical Structure

Liraglutide Chemical Structure

CAS No. : 204656-20-2

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规格 价格 是否有货 数量
1 mg ￥1450
In-stock
5 mg ￥5800
In-stock
10 mg ￥8990
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Liraglutide:

Liraglutide 相关抗体

Top Publications Citing Use of Products

    Liraglutide purchased from MCE. Usage Cited in: Am J Physiol Renal Physiol. 2020 Sep 1;319(3):F458-F468.  [Abstract]

    Representative Western blot showing FN protein abundance in HMCs cultured in media containing 5.5 mM glucose (NG) or 5.5 mM glucose + 19.5 mM mannitol (NG+M) or 25 mM glucose (HG) in the absence or presence of liraglutide at different concentrations (1 nM, 10 nM, 100 nM, 1000 nM) for 24h.

    Liraglutide purchased from MCE. Usage Cited in: Mol Med Rep. 2016 Oct;14(4):3662-8.  [Abstract]

    Effects of Liraglutide treatment on Alp and OC protein expression levels, and matrix mineralization. Following culture in commercial osteogenic differentiation medium for 14 days, MC3T3-E1 cells are cultured for an additional 14 days in basal culture medium with various concentrations of Liraglutide (0, 0.1, 0.5, 1, 2 and 4 nM). MC3T3-E1 cells maintained in DMEM for 28 days with no treatment are used as the NC; cells cultured in the commercial osteogenic differentiation medium for 14 days and in

    • 生物活性

    • 实验参考方法

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used clinically to treat type 2 diabetes mellitus.

    IC50 & Target

    GLP-1 receptor[1]
    体外研究
    (In Vitro)

    Liraglutide binds to the same receptors as does the endogenous metabolic hormone GLP-1. Liraglutide is an injectable drug for the treatment of type 2 diabetes, also can be used to treat obesity in adults with some related comorbidity. Liraglutide activated AMPK/SREBP1 pathway in oxLDL-stimulated Raw264.7 cells[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Liraglutide 相关抗体:
    Clinical Trial
    分子量

    3751.20

    Formula

    C172H265N43O51
    CAS 号
    性状

    固体

    颜色

    White to off-white

    Sequence

    His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-{Lys-N6-[N-(1-oxohexadecyl)-L-g-glutamyl]}-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly
    Sequence Shortening

    HAEGTFTSDVSSYLEGQAA-{Lys-N6-[N-(1-oxohexadecyl)-L-g-glutamyl]}-EFIAWLVRGRG
    中文名称

    利拉鲁肽
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Sealed storage, away from moisture and light

    Powder -80°C 2 years
    -20°C 1 year

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

    溶解性数据
    In Vitro: 

    0.1 M NaOH 中的溶解度 : 12.5 mg/mL (3.33 mM; adjust pH to 8 with 0.1 M NaOH)

    H2O 中的溶解度 : 5 mg/mL (1.33 mM; ultrasonic and warming and adjust pH to 4 with HCl and heat to 60°C)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 0.2666 mL 1.3329 mL 2.6658 mL
    5 mM --- --- ---
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    * 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
    纯度 & 产品资料

    纯度: 99.82%

    COA (191 KB) RP-HPLC (199 KB) 元素分析报告 (206 KB)

    产品使用指南 (1538 KB)
    参考文献
    Cell Assay
    [1]

    Raw264.7 macrophage cells are cultured in Dulbecco's modified Eagle's medium supplemented with 10% fetal bovine serum in a humidified 37°C incubator with 5% CO2. The cells are incubated with oxLDL (50 μg/mL), Liraglutide (0.1, 0.5, 1 and 2 nM) or Exendin-3 (9-39) (1, 10 and 100 nM) alone, or in combination[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    参考文献

    Liraglutide 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    H2O / 0.1 M NaOH 1 mM 0.2666 mL 1.3329 mL 2.6658 mL 6.6645 mL

    * 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Liraglutide204656-20-2利拉鲁肽GCGRGLP ReceptorGlucagon ReceptorInhibitorinhibitorinhibit

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    产品名称：
    Liraglutide
    目录号：
    HY-P0014
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