1. Metabolic Enzyme/Protease
  2. Angiotensin-converting Enzyme (ACE)
  3. Lisinopril

Lisinopril  (Synonyms: 赖诺普利; MK-521)

目录号: HY-18206 纯度: 99.93%
COA 产品使用指南

Lisinopril (MK-521) 是血管紧张素转化酶抑制剂,可作用于高血压,充血性心力衰竭和心脏病等。

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Lisinopril Chemical Structure

Lisinopril Chemical Structure

CAS No. : 76547-98-3

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500 mg ¥500
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Top Publications Citing Use of Products

    Lisinopril purchased from MCE. Usage Cited in: Hum Cell. 2020 Apr;33(2):330-336.  [Abstract]

    After 72 h of incubation, the protein expressions of collagen I, MMP9, α-SMA, smad2, smad3, p-smad2 and p-smad3 in control, TGF-β1 (5 ng/ml), MK-521 (10 μM), TGF-β1+MK-521, silibinin (40 μM) and TGF-β1+MK-521+silibinin are detected by Western blot. GAPDH was used as a loading control.

    Lisinopril purchased from MCE. Usage Cited in: Hum Cell. 2020 Apr;33(2):330-336.  [Abstract]

    HK-2 cells are treated with 0, 5, 10, 20 and 40 μM MK-521 for 48 h, and cell viability was determined by CCK-8 assay. HK-2 cells are treated with 40 μM silibinin or/and 10 μM MK-521 for 48 h, and cell viability was determined by CCK-8 assay.
    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Lisinopril (MK-521) is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks.

    IC50 & Target

    ACE.

    体外研究
    (In Vitro)

    Lisinopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Lisinopril may be used to treat hypertension and symptomatic congestive heart failure, to improve survival in certain individuals following myocardial infarction, and to prevent progression of renal disease in hypertensive patients with diabetes mellitus and microalbuminuria or overt nephropathy[1][2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Clinical Trial
    分子量

    405.49

    Formula

    C21H31N3O5

    CAS 号
    性状

    固体

    颜色

    White to off-white

    中文名称

    赖诺普利;苯丁酸赖脯酸

    结构分类
    初始来源
    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    纯度 & 产品资料

    纯度: 99.93%

    参考文献
    • 摩尔计算器

    • 稀释计算器

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量   浓度   体积   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    产品名称:
    Lisinopril
    目录号:
    HY-18206
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