1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. GABA Receptor
  3. Loreclezole

Loreclezole (Synonyms: R 72063)

目录号: HY-105272
产品使用指南

Loreclezole 是一种抗癫痫药物,是选择性的GABAA 受体 的调节剂,是β2 或β3亚单位包含受体的正向变构调节剂。

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Loreclezole Chemical Structure

Loreclezole Chemical Structure

CAS No. : 117857-45-1

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Size Price Stock Quantity
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ¥1320 In-stock
5 mg ¥1200 In-stock
10 mg ¥1800 In-stock
50 mg ¥6900 In-stock
100 mg ¥11000 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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Description

Loreclezole, an antiepileptic compound, is a selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit containing receptors[1][2].

IC50 & Target

GABAA receptor[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 110 mg/mL (400.68 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6426 mL 18.2129 mL 36.4259 mL
5 mM 0.7285 mL 3.6426 mL 7.2852 mL
10 mM 0.3643 mL 1.8213 mL 3.6426 mL
*请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液。
In Vivo:
  • 1.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (7.58 mM); Clear solution

  • 2.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (7.58 mM); Clear solution

*以上所有助溶剂都可在 MCE 网站选购。
References
Molecular Weight

274.53

Formula

C₁₀H₆Cl₃N₃

CAS No.

117857-45-1

SMILES

Cl/C(C1=C(C=C(Cl)C=C1)Cl)=C\N2C=NC=N2

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
Loreclezole
目录号:
HY-105272
需求量:

Loreclezole

Cat. No.: HY-105272