1. Metabolic Enzyme/Protease
  2. Mitochondrial Metabolism
  3. MSDC-0602

MSDC-0602 

目录号: HY-108022
产品使用指南

MSDC-0602 是一种 PPARγ 保留的噻唑烷二酮类药物 (TZD),与线粒体丙酮酸载体 (MPC) 相互作用并抑制其活性,对治疗 2 型糖尿病有效,且降低 pparγ 介导的副作用的风险。

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MSDC-0602 Chemical Structure

MSDC-0602 Chemical Structure

CAS No. : 1133819-87-0

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Size Price Stock Quantity
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ¥660 In-stock
5 mg ¥600 In-stock
10 mg ¥900 In-stock
50 mg ¥3600 In-stock
100 mg ¥6500 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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Description

MSDC-0602, a PPARγ-sparing thiazolidinedione (TZD), interacts with the mitochondrial pyruvate carrier (MPC) and inhibits its activity and are effective for treatment of type 2 diabetes with reducing risk of PPARγ-mediated side effects[1][2].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (336.56 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6924 mL 13.4622 mL 26.9244 mL
5 mM 0.5385 mL 2.6924 mL 5.3849 mL
10 mM 0.2692 mL 1.3462 mL 2.6924 mL
*请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液。
In Vivo:
  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.60 mM); Clear solution

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.60 mM); Clear solution

  • 3.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.60 mM); Clear solution

*以上所有助溶剂都可在 MCE 网站选购。
References
Molecular Weight

371.41

Formula

C₁₉H₁₇NO₅S

CAS No.

1133819-87-0

SMILES

O=C1C(SC(N1)=O)CC2=CC=C(OCC(C3=CC(OC)=CC=C3)=O)C=C2

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
MSDC-0602
目录号:
HY-108022
需求量:

MSDC-0602

Cat. No.: HY-108022