1. Apoptosis
  2. MDM-2/p53
  3. Pifithrin-β

Pifithrin-β  (Synonyms: PFT β; Cyclic Pifithrin-α)

目录号: HY-16702
产品使用指南

Pifithrin-β (PFT β) 是有效地 p53 抑制剂,IC50 值为 23 μM。

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Pifithrin-β Chemical Structure

Pifithrin-β Chemical Structure

CAS No. : 60477-34-1

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Pifithrin-β 的其他形式现货产品:

Other Forms of Pifithrin-β:

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Top Publications Citing Use of Products

    Pifithrin-β purchased from MCE. Usage Cited in: PLoS One. 2018 Sep 20;13(9):e0203833.  [Abstract]

    Western Blot analysis of TFDP3, p53 and LC3 in whole cell lysates of MDA-MB-231 transfected and treated with indicated plasmids and reagents. Cells in the treatment group are incubated with 20 μM PFT-beta for 24 hours.
    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Pifithrin-β (PFT β) is a potent p53 inhibitor with an IC50 of 23 μM.

    IC50 & Target

    IC50: 23 μM (p53)[1]

    体外研究
    (In Vitro)

    Pifithrin-α, an inhibitor of the p53 protein, is regarded as a lead compound for cancer and neurodegenerative disease therapy. Pifithrin-α is very unstable in culture medium and rapidly converts to its condensation product pifithrin-β (PFT β), the N-acetyl derivative[2]. After 24 h, the viability assay shows that the pretreatments with 1 and 10 μM pifithrin-β exerts neuroprotective effects[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    分子量

    268.38

    Formula

    C16H16N2S

    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.

    纯度 & 产品资料
    参考文献

    Pifithrin-β 相关分类

    • 摩尔计算器

    • 稀释计算器

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量   浓度   体积   分子量 *
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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    目录号:
    HY-16702
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