2. Stem Cell/Wnt Apoptosis
  3. Oct3/4 c-Myc Apoptosis
  4. SB-T-1214

SB-T-1214 (SBT) 是一种紫杉烷类药物。SB-T-1214 可有效抑制干细胞相关基因 (Oct4、Sox2 和 c-Myc) 的表达，并诱导具有耐药性致瘤性 CD133+/CD44+ 细胞的结肠癌球体凋亡 (apoptosis)。SB-T-1214 在 Pgp+ DLD-1 人结肠肿瘤异种移植小鼠模型中有效抑制肿瘤生长。SB-T-1214 可用于抗肿瘤研究，尤其是针对具有耐药性的肿瘤，例如结肠癌、胰腺癌和肾癌。

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SB-T-1214 Chemical Structure

SB-T-1214 Chemical Structure

CAS No. : 178250-23-2

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SB-T-1214 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SB-T-1214 (SBT) is a taxane. SB-T-1214 efficiently inhibits expression of stem cell-related genes (Oct4, Sox2, and c-Myc) and induces apoptosis of colon cancer spheroids with drug resistant tumorigenic CD133+/CD44+ cells. SB-T-1214 strongly represses tumor growth in Pgp+ DLD-1 human colon tumor xenografts mice model. SB-T-1214 can be used for antitumor research, especially against tumors with drug resistance, such as colon, pancreatic and renal cancers[1][2].

体外研究
(In Vitro)

SB-T-1214 (0.5-5000 nM，72 小时) 具有强效的 FR 特异性抗癌活性，对 ID8、MX-1、L1210-FR 和 WI-38 细胞的 IC50 分别为 2.82、1.89、2.66 和 4.89 nM[1]。
SB-T-1214 (0.1-1 μM，48 小时) 在 0.1 μM 浓度下诱导富含 CSC 的结肠癌细胞和球体凋亡，导致漂浮球体的完整性丧失，并在 HCT116、HT29 和 DLD-1 细胞中产生 1.5-3% 的次级球体[2]。
SB-T-1214 (0.1 μM， 24-24 小时) 显著下调 CD133+/CD44+ HCT116、HT29 和 DLD-1 细胞球体中大多数干性基因，如 SOX1、ACAN 和 COL1A1，并抑制多能性标志物 Oct4、Sox2 和 c-Myc 的蛋白表达[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SB-T-1214 相关抗体:

Western Blot Analysis[2]

Cell Line: spheroids from CD133+/CD44+ HCT116 cells
Concentration: 0.1 μM
Incubation Time: 24 h
Result: Significantly inhibited the protein expression of pluripotency markers Oct4, Sox2, and c-Myc in spheroids from CD133+/CD44+ HCT116 cells.

Apoptosis Analysis[2]

Cell Line: spheroids from CD133+/CD44+ HCT116 cells
Concentration: 0.1-1 μM
Incubation Time: 48 h
Result: Induced a loss of integrity of the floating spheroids and apoptosis in more than 90% of the sphere cells.
Induced 89-96% CSC-enriched colon cancer cells apoptosis.
体内研究
(In Vivo)

SB-T-1214 (10-40 mg/kg，腹腔注射，静脉注射，q3d × 3 (第 5、8 和 11 天)) 强烈抑制 Pgp+ DLD-1 人结肠肿瘤异种移植小鼠模型中的肿瘤生长，在 20 mg/kg 时具有良好的疗效[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SCID mice were injected subcutaneously with Pgp+ DLD-1 cells to induce Pgp+ DLD-1 human colon tumor xenografts mice model[1].
Dosage: 10, 20, 40 mg/kg
Administration: i.v., q3d × 3 (day 5, 8, and 11).
Result: Had profound antitumor activity with 100% DLD-1 tumor regression 20 mg/kg and >201 days tumor growth delay.
Induced no significant toxicity with good tolerance and only a 3-5% weight loss during the period of day 15 to day 20.
Reduced tumor volume without expression human EpCAM and CD133.
分子量

853.95

Formula

C45H59NO15
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SB-T-1214 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SB-T-1214178250-23-2Oct3/4c-MycApoptosisPOU5F1Slc22a3MycTaxaneAnticancerPgp+ DLD-1 human colon tumor xenografts mice modelInhibitorinhibitorinhibit

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