1. PROTAC
    Protein Tyrosine Kinase/RTK
  2. SNIPER
    Bcr-Abl

SNIPER(ABL)-024 

目录号: HY-111861
产品使用指南

SNIPER(ABL)-024,由 GNF5 (ABL 抑制剂) 通过 linker 与 LCL161 衍生物 (cIAP1 配体) 组合而成,可有效降解 BCR-ABL 蛋白,DC50 为 5μM。

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SNIPER(ABL)-024 Chemical Structure

SNIPER(ABL)-024 Chemical Structure

CAS No. : 2222355-77-1

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Description

SNIPER(ABL)-024, conjugating GNF5 (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 5μM[1].

References
Molecular Weight

1031.15

Formula

C₅₂H₆₁F₃N₈O₉S

CAS No.

2222355-77-1

SMILES

O=C(NCCOCCOCCOCCOC1=CC(C(C2=CSC([C@H]3N(C([C@H](C4CCCCC4)NC([C@H](C)NC)=O)=O)CCC3)=N2)=O)=CC=C1)C5=CC=CC(C6=NC=NC(NC7=CC=C(OC(F)(F)F)C=C7)=C6)=C5

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
SNIPER(ABL)-024
目录号:
HY-111861
需求量:

SNIPER(ABL)-024

Cat. No.: HY-111861