1. PROTAC
    Protein Tyrosine Kinase/RTK
  2. SNIPER
    Bcr-Abl
  3. SNIPER(ABL)-033

SNIPER(ABL)-033 

目录号: HY-111871
产品使用指南

SNIPER(ABL)-033,由 HG-7-85-01 (ABL 抑制剂) 通过 linker 与 LCL161 衍生物 (cIAP1 配体) 组合而成,可有效降解 BCR-ABL 蛋白,DC50 为 0.3 μM。

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SNIPER(ABL)-033 Chemical Structure

SNIPER(ABL)-033 Chemical Structure

CAS No. : 2222354-18-7

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Description

SNIPER(ABL)-033, conjugating HG-7-85-01 (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 0.3 μM[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

1211.42

Formula

C₆₁H₇₃F₃N₁₀O₉S₂

CAS No.

2222354-18-7

SMILES

CCN1CCN(CC2=C(C(F)(F)F)C=C(NC(C3=CC(C4=NC5=C(N=C(NC(COCCOCCOCCOC6=CC(C(C7=CSC([C@H]8N(C([C@H](C9CCCCC9)NC([C@H](C)NC)=O)=O)CCC8)=N7)=O)=CC=C6)=O)S5)C=C4)=CC=C3)=O)C=C2)CC1

Shipping

Room temperature in continental US; may vary elsewhere

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C1   V1   C2   V2

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产品名称:
SNIPER(ABL)-033
目录号:
HY-111871
需求量:

SNIPER(ABL)-033

Cat. No.: HY-111871